GNAQ

GNAQ
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 2BCJ, 2RGN, 3AH8, 3OHM, 4EKC, 4EKD, 4GNK, 4QJ3, 4QJ4, 4QJ5
Dynodwyr
Cyfenwau	GNAQ, CMC1, G-ALPHA-q, GAQ, SWS, G protein subunit alpha q
Dynodwyr allanol	OMIM: 600998 HomoloGene: 1566 GeneCards: GNAQ
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • nucleotide binding • type 2A serotonin receptor binding • GO:0005097, GO:0005099, GO:0005100 GTPase activator activity • GTP binding • metal ion binding • GO:0001948, GO:0016582 protein binding • GO:0006184 GTPase activity • guanyl nucleotide binding • G protein-coupled receptor binding • signal transducer activity • G-protein beta/gamma-subunit complex binding Cydrannau o'r gell • cytoplasm • cell body • nuclear membrane • bilen • Cellbilen • photoreceptor outer segment • lysosomal membrane • dendrite • extracellular exosome • cnewyllyn cell • heterotrimeric G-protein complex • intracellular anatomical structure Prosesau biolegol • G protein-coupled acetylcholine receptor signaling pathway • skeletal system development • negative regulation of protein kinase activity • neuron remodeling • embryonic digit morphogenesis • protein stabilization • blood coagulation • post-embryonic development • regulation of melanocyte differentiation • activation of phospholipase C activity • entrainment of circadian clock • platelet activation • forebrain neuron development • heart development • maternal behavior • phototransduction, visible light • developmental pigmentation • GO:0072468 signal transduction • GO:0032320, GO:0032321, GO:0032855, GO:0043089, GO:0032854 positive regulation of GTPase activity • glutamate receptor signaling pathway • action potential • adenylate cyclase-activating G protein-coupled receptor signaling pathway • phospholipase C-activating dopamine receptor signaling pathway • G protein-coupled receptor signaling pathway • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • regulation of canonical Wnt signaling pathway Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	2776	n/a
Ensembl	ENSG00000156052	n/a
UniProt	P50148	n/a
RefSeq (mRNA)	NM_002072	n/a
RefSeq (protein)	NP_002063 NP_002063.2	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn GNAQ yw GNAQ a elwir hefyd yn Guanine nucleotide binding protein (G protein), q polypeptide, isoform CRA_c (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 9, band 9q21.2.

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn GNAQ.

• GAQ
• SWS
• CMC1
• G-ALPHA-q

Llyfryddiaeth

• "GNAQ and GNA11 mutations and downstream YAP activation in choroidal nevi. ". Br J Cancer. 2017. PMID 28809862.
• "GNAQ TT(-695/-694)GC Polymorphism Is Associated with Increased Gq Expression, Vascular Reactivity, and Myocardial Injury after Coronary Artery Bypass Surgery. ". Anesthesiology. 2017. PMID 28422819.
• "G protein subunit α q regulates gastric cancer growth via the p53/p21 and MEK/ERK pathways. ". Oncol Rep. 2017. PMID 28350126.
• "Somatic GNAQ Mutation is Enriched in Brain Endothelial Cells in Sturge-Weber Syndrome. ". Pediatr Neurol. 2017. PMID 27919468.
• "Somatic Activating Mutations in GNAQ and GNA11 Are Associated with Congenital Hemangioma.". Am J Hum Genet. 2016. PMID 27058448.