GNAI1

GNAI1
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 1KJY, 1Y3A, 2G83, 2GTP, 2IK8, 2OM2, 2XNS, 3ONW, 3QE0, 3QI2, 3UMR, 3UMS, 4G5Q, 5JS7, 5JS8
Dynodwyr
Cyfenwau	GNAI1, Gi, G protein subunit alpha i1, HG1B, NEDHISB
Dynodwyr allanol	OMIM: 139310 HomoloGene: 74417 GeneCards: GNAI1
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • GTPase activating protein binding • nucleotide binding • G-protein beta/gamma-subunit complex binding • GDP binding • G protein-coupled serotonin receptor binding • signal transducer activity • metal ion binding • GO:0001948, GO:0016582 protein binding • guanyl nucleotide binding • G protein-coupled receptor binding • GTP binding • magnesium ion binding • GO:0006184 GTPase activity Cydrannau o'r gell • cytoplasm • centrosome • bilen • Cellbilen • intracellular anatomical structure • microtubule organizing center • lysosomal membrane • midbody • heterotrimeric G-protein complex • membrane raft • extracellular exosome • Cytosgerbwd • cnewyllyn cell • nucleolus • cell cortex region • cell cortex • GO:0009327 protein-containing complex Prosesau biolegol • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • response to peptide hormone • negative regulation of synaptic transmission • Cellraniad • cell cycle • GO:0072468 signal transduction • regulation of cAMP-mediated signaling • cellular response to forskolin • protein folding • regulation of mitotic spindle organization • positive regulation of protein localization to cell cortex • GO:0015915 transport • G protein-coupled receptor signaling pathway Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	2770	n/a
Ensembl	ENSG00000127955	n/a
UniProt	P63096	n/a
RefSeq (mRNA)	NM_002069 NM_001256414	n/a
RefSeq (protein)	NP_001243343 NP_002060	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn GNAI1 yw GNAI1 a elwir hefyd yn G protein subunit alpha i1 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 7, band 7q21.11.

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn GNAI1.

• Gi

Llyfryddiaeth

• "A Conserved Hydrophobic Core in Gαi1 Regulates G Protein Activation and Release from Activated Receptor. ". J Biol Chem. 2016. PMID 27462082.
• "Conformational dynamics of a G-protein α subunit is tightly regulated by nucleotide binding. ". Proc Natl Acad Sci U S A. 2016. PMID 27298341.
• "Probing Gαi1 protein activation at single-amino acid resolution. ". Nat Struct Mol Biol. 2015. PMID 26258638.
• "Integration of Fourier Transform Infrared Spectroscopy, Fluorescence Spectroscopy, Steady-state Kinetics and Molecular Dynamics Simulations of Gαi1 Distinguishes between the GTP Hydrolysis and GDP Release Mechanism. ". J Biol Chem. 2015. PMID 25979337.
• "Mutation analysis of inhibitory guanine nucleotide binding protein alpha (GNAI) loci in young and familial pituitary adenomas.". PLoS One. 2014. PMID 25291362.