GM2A

GM2A
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 1G13, 1PU5, 1PUB, 1TJJ, 2AF9, 2AG2, 2AG4, 2AG9
Dynodwyr
Cyfenwau	GM2A, GM2-AP, SAP-3, GM2 ganglioside activator, GM2AP, ganglioside GM2 activator
Dynodwyr allanol	OMIM: 613109 HomoloGene: 349 GeneCards: GM2A
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • lipid transporter activity • phospholipase activator activity • beta-N-acetylgalactosaminidase activity • beta-N-acetylhexosaminidase activity • GO:0010577 enzyme activator activity • hydrolase activity • sphingolipid activator protein activity Cydrannau o'r gell • cytoplasm • apical cortex • lysosomal lumen • mitocondria • potassium:proton exchanging ATPase complex • cytoplasmic side of plasma membrane • lysosome • extracellular exosome • extracellular region • azurophil granule lumen • basolateral plasma membrane • apical plasma membrane Prosesau biolegol • positive regulation of hydrolase activity • lipid transport • glycosphingolipid metabolic process • neuromuscular process controlling balance • lipid metabolism • lipid storage • nervous system process • learning or memory • oligosaccharide catabolic process • ganglioside metabolic process • ganglioside catabolic process • sphingolipid metabolic process • neutrophil degranulation • GO:0048554 positive regulation of catalytic activity Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	2760	n/a
Ensembl	ENSG00000196743	n/a
UniProt	P17900	n/a
RefSeq (mRNA)	NM_001167607 NM_000405	n/a
RefSeq (protein)	NP_000396 NP_001161079	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn GM2A yw GM2A a elwir hefyd yn Ganglioside GM2 activator (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 5, band 5q33.1.

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn GM2A.

• SAP-3
• GM2-AP

Llyfryddiaeth

• "GM2 gangliosidosis AB variant: novel mutation from India - a case report with a review. ". BMC Pediatr. 2016. PMID 27402091.
• "Neuronal sphingolipidoses: Membrane lipids and sphingolipid activator proteins regulate lysosomal sphingolipid catabolism. ". Biochimie. 2016. PMID 27157270.
• "Identification of ganglioside GM2 activator playing a role in cancer cell migration through proteomic analysis of breast cancer secretomes. ". Cancer Sci. 2016. PMID 27002480.
• "Membrane lipids regulate ganglioside GM2 catabolism and GM2 activator protein activity. ". J Lipid Res. 2015. PMID 26175473.
• "In cellulo examination of a beta-alpha hybrid construct of beta-hexosaminidase A subunits, reported to interact with the GM2 activator protein and hydrolyze GM2 ganglioside.". PLoS One. 2013. PMID 23483939.