GLRX2

GLRX2
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 2CQ9, 2FLS, 2HT9
Dynodwyr
Cyfenwau	GLRX2, CGI-133, GRX2, glutaredoxin 2
Dynodwyr allanol	OMIM: 606820 HomoloGene: 41098 GeneCards: GLRX2
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • metal ion binding • arsenate reductase (glutaredoxin) activity • electron transfer activity • glutathione disulfide oxidoreductase activity • iron-sulfur cluster binding • protein-disulfide reductase activity • 2 iron, 2 sulfur cluster binding • GO:0030508 protein disulfide isomerase activity Cydrannau o'r gell • nucleoplasm • mitocondria • mitochondrial matrix • cnewyllyn cell • intracellular membrane-bounded organelle • neuronal cell body • dendrite Prosesau biolegol • glutathione metabolic process • DNA protection • response to temperature stimulus • response to redox state • regulation of signal transduction • GO:0097285 apoptotic process • GO:0010260 heneiddio • GO:0009373 regulation of transcription, DNA-templated • response to organic substance • response to hydrogen peroxide • cell differentiation • cellular response to superoxide • cell redox homeostasis • electron transport chain Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	51022	n/a
Ensembl	ENSG00000023572	n/a
UniProt	Q9NS18	n/a
RefSeq (mRNA)	NM_001243399 NM_016066 NM_197962	n/a
RefSeq (protein)	NP_001230328 NP_057150 NP_932066	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn GLRX2 yw GLRX2 a elwir hefyd yn Glutaredoxin 2 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 1, band 1q31.2.

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn GLRX2.

• GRX2
• CGI-133

Llyfryddiaeth

• "Two types of human malignant melanoma cell lines revealed by expression patterns of mitochondrial and survival-apoptosis genes: implications for malignant melanoma therapy. ". Mol Cancer Ther. 2009. PMID 19383853.
• "Oxidative disassembly of the [2Fe-2S] cluster of human Grx2 and redox regulation in the mitochondria. ". Biochemistry. 2009. PMID 19292455.
• "Glutaredoxin 2a, a mitochondrial isoform, plays a protective role in a human cell line under serum deprivation. ". Mol Biol Rep. 2012. PMID 21735102.
• "Glutaredoxin 2 prevents H(2)O(2)-induced cell apoptosis by protecting complex I activity in the mitochondria. ". Biochim Biophys Acta. 2010. PMID 20547138.
• "In vivo fluorescent detection of Fe-S clusters coordinated by human GRX2.". Chem Biol. 2009. PMID 20064440.