GLP1R

GLP1R
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 3C59, 3C5T, 3IOL, 4ZGM
Dynodwyr
Cyfenwau	GLP1R, glucagon-like peptide 1 receptor, GLP-1, GLP-1-R, GLP-1R, glucagon like peptide 1 receptor
Dynodwyr allanol	OMIM: 138032 HomoloGene: 1558 GeneCards: GLP1R
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • G protein-coupled peptide receptor activity • G protein-coupled receptor activity • signal transducer activity • GO:0001948, GO:0016582 protein binding • glucagon receptor activity • transmembrane signaling receptor activity • glucagon-like peptide 1 receptor activity • peptide hormone binding Cydrannau o'r gell • integral component of membrane • bilen • Cellbilen • intracellular anatomical structure • integral component of plasma membrane Prosesau biolegol • regulation of heart contraction • regulation of insulin secretion • positive regulation of cytosolic calcium ion concentration • cellular response to glucagon stimulus • activation of adenylate cyclase activity • cell surface receptor signaling pathway • positive regulation of blood pressure • learning or memory • cAMP-mediated signaling • GO:0072468 signal transduction • adenylate cyclase-activating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • response to psychosocial stress Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	2740	n/a
Ensembl	ENSG00000112164	n/a
UniProt	P43220	n/a
RefSeq (mRNA)	NM_002062	n/a
RefSeq (protein)	NP_002053	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn GLP1R yw GLP1R a elwir hefyd yn Glucagon like peptide 1 receptor (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 6, band 6p21.2.

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn GLP1R.

• GLP-1
• GLP-1R
• GLP-1-R

Llyfryddiaeth

• "Purification of family B G protein-coupled receptors using nanodiscs: Application to human glucagon-like peptide-1 receptor. ". PLoS One. 2017. PMID 28609478.
• "Crystal structure of the GLP-1 receptor bound to a peptide agonist. ". Nature. 2017. PMID 28562585.
• "Genetically encoded photocross-linkers determine the biological binding site of exendin-4 peptide in the N-terminal domain of the intact human glucagon-like peptide-1 receptor (GLP-1R). ". J Biol Chem. 2017. PMID 28283573.
• "Real-World Glycemic Control from GLP-1RA Therapy with and Without Concurrent Insulin in Patients with Type 2 Diabetes. ". J Manag Care Spec Pharm. 2017. PMID 28230449.
• "Immunohistochemical assessment of glucagon-like peptide 1 receptor (GLP-1R) expression in the pancreas of patients with type 2 diabetes.". Diabetes Obes Metab. 2017. PMID 28094469.