GGPS1

GGPS1
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 2Q80
Dynodwyr
Cyfenwau	GGPS1, GGPPS, GGPPS1, geranylgeranyl diphosphate synthase 1, MDHLO, MUDHLOV
Dynodwyr allanol	OMIM: 606982 HomoloGene: 31267 GeneCards: GGPS1
EC number	2.5.1.1
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • transferase activity • farnesyltranstransferase activity • GO:0001948, GO:0016582 protein binding • metal ion binding • dimethylallyltranstransferase activity • geranyltranstransferase activity • identical protein binding Cydrannau o'r gell • cytoplasm • cytosol Prosesau biolegol • cholesterol biosynthetic process • farnesyl diphosphate biosynthetic process • geranyl diphosphate biosynthetic process • geranylgeranyl diphosphate biosynthetic process • isoprenoid biosynthetic process • isoprenoid metabolic process • regulation of cholesterol biosynthetic process Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	9453	n/a
Ensembl	ENSG00000152904	n/a
UniProt	O95749	n/a
RefSeq (mRNA)	NM_001037277 NM_001037278 NM_004837 NM_001371477 NM_001371478	n/a
RefSeq (protein)	NP_001032354 NP_001032355 NP_001358406 NP_001358407 NP_004828 NP_001032354.1	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn GGPS1 yw GGPS1 a elwir hefyd yn Geranylgeranyl diphosphate synthase 1, isoform CRA_a a Geranylgeranyl diphosphate synthase 1 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 1, band 1q42.3.

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn GGPS1.

• GGPPS
• GGPPS1

Llyfryddiaeth

• "Human geranylgeranyl diphosphate synthase is an octamer in solution. ". J Biochem. 2007. PMID 17646172.
• "Farnesyl transferase inhibitor resistance probed by target mutagenesis. ". Blood. 2007. PMID 17536018.
• "GGPS1 Mutation and Atypical Femoral Fractures with Bisphosphonates. ". N Engl J Med. 2017. PMID 28467865.
• "GGPPS1 predicts the biological character of hepatocellular carcinoma in patients with cirrhosis. ". BMC Cancer. 2014. PMID 24716791.
• "cDNA cloning, chromosome mapping and expression characterization of human geranylgeranyl pyrophosphate synthase.". Sci China C Life Sci. 2000. PMID 18726356.