GDF5

GDF5
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 1WAQ, 2BHK, 3EVS, 3QB4
Dynodwyr
Cyfenwau	GDF5, BDA1C, BMP-14, BMP14, CDMP1, LAP-4, LAP4, OS5, SYM1B, SYNS2, growth differentiation factor 5, DUPANS
Dynodwyr allanol	OMIM: 601146 HomoloGene: 468 GeneCards: GDF5
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • cytokine activity • BMP binding • GO:0001948, GO:0016582 protein binding • identical protein binding • transforming growth factor beta receptor binding • growth factor activity • signaling receptor binding Cydrannau o'r gell • bilen • Cellbilen • extracellular region • extracellular space Prosesau biolegol • regulation of apoptotic process • GO:1904089 negative regulation of neuron apoptotic process • forelimb morphogenesis • negative regulation of mesenchymal cell apoptotic process • regulation of MAPK cascade • SMAD protein signal transduction • chondrocyte differentiation • cell development • regulation of multicellular organism growth • cell-cell signaling • positive regulation of pathway-restricted SMAD protein phosphorylation • hindlimb morphogenesis • chondroblast differentiation • cartilage development • negative regulation of chondrocyte differentiation • transmembrane receptor protein serine/threonine kinase signaling pathway • embryonic limb morphogenesis • positive regulation of chondrocyte differentiation • positive regulation of neuron differentiation • negative regulation of epithelial cell proliferation • positive regulation of BMP signaling pathway • transforming growth factor beta receptor signaling pathway • response to mechanical stimulus • ossification involved in bone remodeling • regulation of signaling receptor activity • regulation of SMAD protein signal transduction • BMP signaling pathway Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	8200	n/a
Ensembl	ENSG00000125965	n/a
UniProt	P43026	n/a
RefSeq (mRNA)	NM_000557 NM_001319138	n/a
RefSeq (protein)	NP_000548 NP_001306067	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn GDF5 yw GDF5 a elwir hefyd yn Growth differentiation factor 5 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 20, band 20q11.22.

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn GDF5.

• OS5
• LAP4
• BDA1C
• BMP14
• CDMP1
• LAP-4
• SYM1B
• SYNS2
• BMP-14

Llyfryddiaeth

• "Association of BMP-14 rs143383 ploymorphism with its susceptibility to osteoarthritis: A meta-analysis and systematic review according to PRISMA guideline. ". Medicine (Baltimore). 2017. PMID 29049177.
• "A consistent and potentially exploitable response during chondrogenesis of mesenchymal stem cells from osteoarthritis patients to the protein encoded by the susceptibility gene GDF5. ". PLoS One. 2017. PMID 28481944.
• "Novel homozygous sequence variants in the GDF5 gene underlie acromesomelic dysplasia type-grebe in consanguineous families. ". Congenit Anom (Kyoto). 2017. PMID 27577507.
• "Adenovirus-mediated GDF-5 promotes the extracellular matrix expression in degenerative nucleus pulposus cells. ". J Zhejiang Univ Sci B. 2016. PMID 26739524.
• "A comprehensive meta-analysis of association between genetic variants of GDF5 and osteoarthritis of the knee, hip and hand.". Inflamm Res. 2015. PMID 25894512.