GCHFR

GCHFR
Dynodwyr
Cyfenwau	GCHFR, GFRP, HsT16933, P35, GTP cyclohydrolase I feedback regulator
Dynodwyr allanol	OMIM: 602437 HomoloGene: 3849 GeneCards: GCHFR
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • GTP cyclohydrolase binding • GO:0048551 enzyme inhibitor activity • amino acid binding • GO:0001948, GO:0016582 protein binding • enzyme binding • GTP-dependent protein binding Cydrannau o'r gell • cytoplasm • cytosol • nuclear membrane • bilen • melanosome • dendrite • cnewyllyn cell • nucleoplasm • GO:0009327 protein-containing complex Prosesau biolegol • nitric oxide biosynthetic process • protein heterooligomerization • negative regulation of GTP cyclohydrolase I activity • neurotransmitter metabolic process • negative regulation of biosynthetic process • GO:0034622 protein-containing complex assembly Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	2644	n/a
Ensembl	ENSG00000137880	n/a
UniProt	P30047	n/a
RefSeq (mRNA)	NM_005258	n/a
RefSeq (protein)	NP_005249	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn GCHFR yw GCHFR a elwir hefyd yn GTP cyclohydrolase I feedback regulator (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 15, band 15q15.1.

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn GCHFR.

• P35
• GFRP
• HsT16933

Llyfryddiaeth

• "A polymorphism of the GTP-cyclohydrolase I feedback regulator gene alters transcriptional activity and may affect response to SSRI antidepressants. ". Pharmacogenomics J. 2011. PMID 20351752.
• "Over-expression of GTP-cyclohydrolase 1 feedback regulatory protein attenuates LPS and cytokine-stimulated nitric oxide production. ". Vasc Med. 2008. PMID 18372436.
• "Bacterial lipopolysaccharide down-regulates expression of GTP cyclohydrolase I feedback regulatory protein. ". J Biol Chem. 2002. PMID 11799107.
• "H(2)O(2) increases de novo synthesis of (6R)-L-erythro-5,6,7,8-tetrahydrobiopterin via GTP cyclohydrolase I and its feedback regulatory protein in vitiligo. ". J Inherit Metab Dis. 2009. PMID 19101819.
• "Changes in tetrahydrobiopterin levels in endothelial cells and adult cardiomyocytes induced by LPS and hydrogen peroxide--a role for GFRP?". Free Radic Biol Med. 2005. PMID 15649650.