GBP1

GBP1
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 1DG3, 1F5N, 2B8W, 2B92, 2BC9, 2D4H
Dynodwyr
Cyfenwau	GBP1, guanylate binding protein 1
Dynodwyr allanol	OMIM: 600411 HomoloGene: 133759 GeneCards: GBP1
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • nucleotide binding • Hsp90 protein binding • spectrin binding • GO:0001948, GO:0016582 protein binding • identical protein binding • enzyme binding • actin binding • hydrolase activity • GO:0019974 cytokine binding • GO:0006184 GTPase activity • GTP binding • GDP binding • protein homodimerization activity Cydrannau o'r gell • cytosol • bilen • Golgi membrane • Cellbilen • extracellular region • cytoplasm • Golgi apparatus • vesicle membrane • actin cytoskeleton • GO:0016023 cytoplasmic vesicle Prosesau biolegol • immune system process • interferon-gamma-mediated signaling pathway • negative regulation of T cell receptor signaling pathway • negative regulation of protein localization to plasma membrane • defense response to virus • regulation of calcium-mediated signaling • negative regulation of ERK1 and ERK2 cascade • negative regulation of substrate adhesion-dependent cell spreading • regulation of protein localization to plasma membrane • protein homooligomerization • cellular response to interferon-gamma • cellular response to interleukin-1 • cellular response to tumor necrosis factor • protein localization to vacuole Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	2633	n/a
Ensembl	ENSG00000117228	n/a
UniProt	P32455	n/a
RefSeq (mRNA)	NM_002053	n/a
RefSeq (protein)	NP_002044	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn GBP1 yw GBP1 a elwir hefyd yn Guanylate binding protein 1 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 1, band 1p22.2.

Llyfryddiaeth

• "Guanylate-Binding Protein-1 protects ovarian cancer cell lines but not breast cancer cell lines from killing by paclitaxel. ". Biochem Biophys Res Commun. 2016. PMID 27590579.
• "Tetrameric assembly of hGBP1 is crucial for both stimulated GMP formation and antiviral activity. ". Biochem J. 2016. PMID 27071416.
• "Human GBP1 does not localize to pathogen vacuoles but restricts Toxoplasma gondii. ". Cell Microbiol. 2016. PMID 26874079.
• "Guanylate-binding protein 1 (GBP1) promotes lymph node metastasis in human esophageal squamous cell carcinoma. ". Discov Med. 2015. PMID 26760981.
• "Guanine nucleotide-binding protein 1 is one of the key molecules contributing to cancer cell radioresistance.". Cancer Sci. 2014. PMID 25098609.