GATM

GATM
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 1JDW, 1JDX, 2JDW, 2JDX, 3JDW, 4JDW, 5JDW, 6JDW, 7JDW, 8JDW, 9JDW
Dynodwyr
Cyfenwau	GATM, AGAT, AT, CCDS3, glycine amidinotransferase, FRTS1
Dynodwyr allanol	OMIM: 602360 HomoloGene: 1136 GeneCards: GATM
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • transferase activity • glycine amidinotransferase activity • amidinotransferase activity Cydrannau o'r gell • bilen • cytoplasm • mitochondrial inner membrane • extracellular exosome • mitochondrial intermembrane space • mitocondria Prosesau biolegol • creatine biosynthetic process • creatine metabolic process • multicellular organism development • learning or memory • muscle atrophy • positive regulation of cold-induced thermogenesis Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	2628	n/a
Ensembl	ENSG00000171766	n/a
UniProt	P50440	n/a
RefSeq (mRNA)	NM_001482 NM_001321015	n/a
RefSeq (protein)	NP_001307944 NP_001473	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn GATM yw GATM a elwir hefyd yn Glycine amidinotransferase (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 15, band 15q21.1.

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn GATM.

• AT
• AGAT
• CCDS3

Llyfryddiaeth

• "GATM polymorphism associated with the risk for statin-induced myopathy does not replicate in case-control analysis of 715 dyslipidemic individuals. ". Cell Metab. 2015. PMID 25863251.
• "Genome-wide association study identifies 3 genomic loci significantly associated with serum levels of homoarginine: the AtheroRemo Consortium. ". Circ Cardiovasc Genet. 2013. PMID 24047826.
• "Promiscuous activity of arginine:glycine amidinotransferase is responsible for the synthesis of the novel cardiovascular risk factor homoarginine. ". FEBS Lett. 2012. PMID 23010440.
• "l-arginine:glycine amidinotransferase (AGAT) deficiency: clinical presentation and response to treatment in two patients with a novel mutation. ". Mol Genet Metab. 2010. PMID 20682460.
• "Myocardial expression of the arginine:glycine amidinotransferase gene is elevated in heart failure and normalized after recovery: potential implications for local creatine synthesis.". Circulation. 2006. PMID 16820567.