GATA1

GATA1
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 1GNF, 1Y0J, 2L5E, 2L6Y, 2L6Z, 3VD6, 3VEK
Dynodwyr
Cyfenwau	GATA1, ERYF1, GATA-1, GF-1, GF1, NF-E1, NFE1, XLANP, XLTDA, XLTT, GATA binding protein 1
Dynodwyr allanol	OMIM: 305371 HomoloGene: 1549 GeneCards: GATA1
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • C2H2 zinc finger domain binding • GO:0000975 transcription cis-regulatory region binding • sequence-specific DNA binding • RNA polymerase II core promoter sequence-specific DNA binding • DNA binding • p53 binding • DNA binding, bending • chromatin DNA binding • GO:0001077, GO:0001212, GO:0001213, GO:0001211, GO:0001205 DNA-binding transcription activator activity, RNA polymerase II-specific • GO:0001158 cis-regulatory region sequence-specific DNA binding • RNA polymerase II transcription regulatory region sequence-specific DNA binding • GO:0001948, GO:0016582 protein binding • GO:0000980 RNA polymerase II cis-regulatory region sequence-specific DNA binding • chromatin binding • GO:0001131, GO:0001151, GO:0001130, GO:0001204 DNA-binding transcription factor activity • GO:0001078, GO:0001214, GO:0001206 DNA-binding transcription repressor activity, RNA polymerase II-specific • zinc ion binding • metal ion binding • GO:0001200, GO:0001133, GO:0001201 DNA-binding transcription factor activity, RNA polymerase II-specific Cydrannau o'r gell • cnewyllyn cell • nucleoplasm • transcription repressor complex • transcription regulator complex • protein-DNA complex Prosesau biolegol • negative regulation of cell population proliferation • negative regulation of transcription regulatory region DNA binding • eosinophil fate commitment • in utero embryonic development • regulation of glycoprotein biosynthetic process • cellular response to thyroid hormone stimulus • blood coagulation • erythrocyte differentiation • platelet formation • positive regulation of osteoblast proliferation • transcription by RNA polymerase II • platelet aggregation • negative regulation of extrinsic apoptotic signaling pathway in absence of ligand • GO:0009373 regulation of transcription, DNA-templated • regulation of primitive erythrocyte differentiation • GO:0060469, GO:0009371 positive regulation of transcription, DNA-templated • regulation of definitive erythrocyte differentiation • cell-cell signaling • embryonic hemopoiesis • cell development • positive regulation of erythrocyte differentiation • GO:0003257, GO:0010735, GO:1901228, GO:1900622, GO:1904488 positive regulation of transcription by RNA polymerase II • megakaryocyte differentiation • dendritic cell differentiation • positive regulation of peptidyl-tyrosine phosphorylation • negative regulation of bone mineralization • GO:1901227 negative regulation of transcription by RNA polymerase II • male gonad development • myeloid cell differentiation • negative regulation of apoptotic process • homeostasis of number of cells within a tissue • transcription, DNA-templated • basophil differentiation • eosinophil differentiation • erythrocyte development • regulation of megakaryocyte differentiation • regulation of hematopoietic stem cell differentiation • heart development • animal organ morphogenesis • tissue development • anatomical structure formation involved in morphogenesis • digestive tract development Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	2623	n/a
Ensembl	ENSG00000102145	n/a
UniProt	P15976	n/a
RefSeq (mRNA)	NM_002049	n/a
RefSeq (protein)	NP_002040	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn GATA1 yw GATA1 a elwir hefyd yn GATA binding protein 1 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom X dynol, band Xp11.23.

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn GATA1.

• GF1
• GF-1
• NFE1
• XLTT
• ERYF1
• NF-E1
• XLANP
• XLTDA
• GATA-1

Llyfryddiaeth

• "A neonate with a unique non-Down syndrome transient proliferative megakaryoblastic disease. ". Pediatr Blood Cancer. 2017. PMID 27667142.
• "GATA1 mutations in a cohort of Malaysian children with Down syndrome-associated myeloid disorder. ". Singapore Med J. 2016. PMID 27353457.
• "Systematic Cellular Disease Models Reveal Synergistic Interaction of Trisomy 21 and GATA1 Mutations in Hematopoietic Abnormalities. ". Cell Rep. 2016. PMID 27134169.
• "A Child With Dyserythropoietic Anemia and Megakaryocyte Dysplasia Due to a Novel 5'UTR GATA1s Splice Mutation. ". Pediatr Blood Cancer. 2016. PMID 26713410.
• "Long-term outcome for Down syndrome patients with hematopoietic disorders.". J Formos Med Assoc. 2016. PMID 26234152.