GADD45A

GADD45A
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 2KG4
Dynodwyr
Cyfenwau	GADD45A, DDIT1, GADD45, growth arrest and DNA damage inducible alpha
Dynodwyr allanol	OMIM: 126335 HomoloGene: 1449 GeneCards: GADD45A
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • GO:0001948, GO:0016582 protein binding • kinase binding • protein homodimerization activity • protein heterodimerization activity • protein N-terminus binding • RNA polymerase II core promoter sequence-specific DNA binding Cydrannau o'r gell • cytoplasm • cnewyllyn cell • nucleoplasm • nuclear speck Prosesau biolegol • GO:0097285 apoptotic process • centrosome cycle • regulation of cyclin-dependent protein serine/threonine kinase activity • negative regulation of protein kinase activity • signal transduction in response to DNA damage • response to stress • positive regulation of JNK cascade • regulation of cell cycle • cellular response to DNA damage stimulus • cellular response to mechanical stimulus • positive regulation of reactive oxygen species metabolic process • positive regulation of apoptotic process • cellular response to ionizing radiation • cell cycle • GO:0100026 DNA repair • positive regulation of p38MAPK cascade • DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	1647	n/a
Ensembl	ENSG00000116717	n/a
UniProt	P24522	n/a
RefSeq (mRNA)	NM_001924 NM_001199741 NM_001199742	n/a
RefSeq (protein)	NP_001186670 NP_001186671 NP_001915	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn GADD45A yw GADD45A a elwir hefyd yn Growth arrest and DNA damage inducible alpha (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 1, band 1p31.3.

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn GADD45A.

• DDIT1
• GADD45

Llyfryddiaeth

• "GADD45α is involved in the apoptosis of lymphocytes induced by riboflavin and ultraviolet light. ". Transfusion. 2017. PMID 27905125.
• "A Protective Mechanism of Visible Red Light in Normal Human Dermal Fibroblasts: Enhancement of GADD45A-Mediated DNA Repair Activity. ". J Invest Dermatol. 2017. PMID 27729279.
• "GADD45 proteins inhibit HIV-1 replication through specific suppression of HIV-1 transcription. ". Virology. 2016. PMID 26994425.
• "The GADD45A (1506T>C) Polymorphism Is Associated with Ovarian Cancer Susceptibility and Prognosis. ". PLoS One. 2015. PMID 26422378.
• "Serum GADD45a methylation is a useful biomarker to distinguish benign vs malignant prostate disease.". Br J Cancer. 2015. PMID 26171936.