GAD2

GAD2
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 1ES0, 2OKK
Dynodwyr
Cyfenwau	GAD2, GAD65, glutamate decarboxylase 2
Dynodwyr allanol	OMIM: 138275 HomoloGene: 20223 GeneCards: GAD2
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • GO:0001948, GO:0016582 protein binding • catalytic activity • lyase activity • protein heterodimerization activity • pyridoxal phosphate binding • carboxy-lyase activity • glutamate binding • glutamate decarboxylase activity Cydrannau o'r gell • cytoplasm • cytosol • Golgi apparatus • bilen • Golgi membrane • Cellbilen • clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane • synapse • inhibitory synapse • synaptic vesicle membrane • axon • cell junction • perinuclear region of cytoplasm • anchored component of membrane • presynaptic membrane • GO:0016023 cytoplasmic vesicle Prosesau biolegol • carboxylic acid metabolic process • neurotransmitter biosynthetic process • glutamate decarboxylation to succinate • chemical synaptic transmission • GO:0010554 neurotransmitter secretion Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	2572	n/a
Ensembl	ENSG00000136750	n/a
UniProt	Q05329	n/a
RefSeq (mRNA)	NM_001134366 NM_000818	n/a
RefSeq (protein)	NP_000809 NP_001127838	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn GAD2 yw GAD2 a elwir hefyd yn Glutamate decarboxylase 2 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 10, band 10p12.1.

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn GAD2.

• GAD65

Llyfryddiaeth

• "Identification of GAD65 AA 114-122 reactive 'memory-like' NK cells in newly diagnosed Type 1 diabetic patients by HLA-class I pentamers. ". PLoS One. 2017. PMID 29236750.
• "Immuno-chemistry of hydroxyl radical modified GAD-65: A possible role in experimental and human diabetes mellitus. ". IUBMB Life. 2015. PMID 26362234.
• "Relationship between serum GAD-Ab and the genetic polymorphisms of GAD2 and type 2 diabetes mellitus. ". Genet Mol Res. 2015. PMID 25966064.
• "Plasma GAD65, a Marker for Early β-Cell Loss After Intraportal Islet Cell Transplantation in Diabetic Patients. ". J Clin Endocrinol Metab. 2015. PMID 25816051.
• "Lower glutamic acid decarboxylase 65-kDa isoform messenger RNA and protein levels in the prefrontal cortex in schizoaffective disorder but not schizophrenia.". Biol Psychiatry. 2015. PMID 24993056.