GABPA

GABPA
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 1AWC, 1SXD, 2JUO
Dynodwyr
Cyfenwau	GABPA, E4TF1-60, E4TF1A, NFT2, NRF2, NRF2A, RCH04A07, GA binding protein transcription factor alpha subunit, GA binding protein transcription factor subunit alpha
Dynodwyr allanol	OMIM: 600609 HomoloGene: 1543 GeneCards: GABPA
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • DNA binding • sequence-specific DNA binding • GO:0001131, GO:0001151, GO:0001130, GO:0001204 DNA-binding transcription factor activity • GO:0001077, GO:0001212, GO:0001213, GO:0001211, GO:0001205 DNA-binding transcription activator activity, RNA polymerase II-specific • GO:0001105 transcription coactivator activity • chromatin binding • GO:0000980 RNA polymerase II cis-regulatory region sequence-specific DNA binding • GO:0001948, GO:0016582 protein binding • protein heterodimerization activity • GO:0001200, GO:0001133, GO:0001201 DNA-binding transcription factor activity, RNA polymerase II-specific Cydrannau o'r gell • nucleoplasm • cnewyllyn cell Prosesau biolegol • cell differentiation • GO:0009373 regulation of transcription, DNA-templated • GO:0044324, GO:0003256, GO:1901213, GO:0046019, GO:0046020, GO:1900094, GO:0061216, GO:0060994, GO:1902064, GO:0003258, GO:0072212 regulation of transcription by RNA polymerase II • mitochondrion organization • in utero embryonic development • GO:1901227 negative regulation of transcription by RNA polymerase II • negative regulation of megakaryocyte differentiation • transcription, DNA-templated • GO:0003257, GO:0010735, GO:1901228, GO:1900622, GO:1904488 positive regulation of transcription by RNA polymerase II • transcription by RNA polymerase II • GO:1901313 positive regulation of gene expression • cellular response to dopamine • blastocyst formation Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	2551	n/a
Ensembl	ENSG00000154727	n/a
UniProt	Q06546 Q8IYS3	n/a
RefSeq (mRNA)	NM_001197297 NM_002040	n/a
RefSeq (protein)	NP_001184226 NP_002031 NP_002031.2	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn GABPA yw GABPA a elwir hefyd yn GA binding protein transcription factor, alpha subunit 60kDa a GA binding protein transcription factor alpha subunit (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 21, band 21q21.3.

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn GABPA.

• NFT2
• NRF2
• NRF2A
• E4TF1A
• E4TF1-60
• RCH04A07

Llyfryddiaeth

• "GABPA predicts prognosis and inhibits metastasis of hepatocellular carcinoma. ". BMC Cancer. 2017. PMID 28549418.
• "Human Lineage-Specific Transcriptional Regulation through GA-Binding Protein Transcription Factor Alpha (GABPa). ". Mol Biol Evol. 2016. PMID 26814189.
• "Clinical characterisation of the CABP4-related retinal phenotype. ". Br J Ophthalmol. 2013. PMID 23099293.
• "The rs12594956 polymorphism in the NRF-2 gene is associated with top-level Spanish athlete's performance status. ". J Sci Med Sport. 2013. PMID 22749526.
• "An interaction between Nrf2 polymorphisms and smoking status affects annual decline in FEV1: a longitudinal retrospective cohort study.". BMC Med Genet. 2011. PMID 21774808.