GABARAPL2

GABARAPL2
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 4CO7
Dynodwyr
Cyfenwau	GABARAPL2, ATG8, ATG8C, GATE-16, GATE16, GEF-2, GEF2, GABA type A receptor associated protein like 2
Dynodwyr allanol	OMIM: 607452 HomoloGene: 68550 GeneCards: GABARAPL2
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • GABA receptor binding • microtubule binding • ATPase binding • GO:0001948, GO:0016582 protein binding • beta-tubulin binding • SNARE binding • ubiquitin protein ligase binding Cydrannau o'r gell • cytoplasm • Golgi apparatus • Golgi membrane • intracellular anatomical structure • autophagosome • autophagosome membrane • GO:0016023 cytoplasmic vesicle • cytosol Prosesau biolegol • positive regulation of ATP-dependent activity • autophagy • protein transport • negative regulation of proteasomal protein catabolic process • intra-Golgi vesicle-mediated transport • macroautophagy • GO:0000046 autophagosome maturation • autophagosome assembly • autophagy of mitochondrion • cellular response to nitrogen starvation Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	11345	n/a
Ensembl	ENSG00000034713	n/a
UniProt	P60520	n/a
RefSeq (mRNA)	NM_007285	n/a
RefSeq (protein)	NP_009216	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn GABARAPL2 yw GABARAPL2 a elwir hefyd yn GABA(A) receptor-associated protein-like 2, isoform CRA_a a GABA type A receptor associated protein like 2 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 16, band 16q23.1.

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn GABARAPL2.

• ATG8
• GEF2
• ATG8C
• GEF-2
• GATE16
• GATE-16

Llyfryddiaeth

• "Inhibition of GATE-16 attenuates ATRA-induced neutrophil differentiation of APL cells and interferes with autophagosome formation. ". Biochem Biophys Res Commun. 2013. PMID 23891751.
• "The Legionella effector RavZ inhibits host autophagy through irreversible Atg8 deconjugation. ". Science. 2012. PMID 23112293.
• "Genetic variants in autophagy associated genes are associated with DNA damage levels in Chinese population. ". Gene. 2017. PMID 28512061.
• "Conformational Polymorphism in Autophagy-Related Protein GATE-16. ". Biochemistry. 2015. PMID 26284781.
• "In vitro assays of lipidation of Mammalian Atg8 homologs.". Curr Protoc Cell Biol. 2014. PMID 25181299.