FZD8

FZD8
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 1IJY, 4F0A
Dynodwyr
Cyfenwau	FZD8, FZ-8, hFZ8, frizzled class receptor 8
Dynodwyr allanol	OMIM: 606146 HomoloGene: 40606 GeneCards: FZD8
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • transmembrane signaling receptor activity • signaling receptor binding • ubiquitin protein ligase binding • GO:0001948, GO:0016582 protein binding • signal transducer activity • PDZ domain binding • G protein-coupled receptor activity • Wnt-protein binding • Wnt-activated receptor activity Cydrannau o'r gell • integral component of membrane • bilen • Cellbilen • Golgi apparatus • Wnt-Frizzled-LRP5/6 complex Prosesau biolegol • positive regulation of protein phosphorylation • positive regulation of JUN kinase activity • cell surface receptor signaling pathway • G protein-coupled receptor signaling pathway • angiogenesis • GO:0003257, GO:0010735, GO:1901228, GO:1900622, GO:1904488 positive regulation of transcription by RNA polymerase II • multicellular organism development • GO:1901227 negative regulation of transcription by RNA polymerase II • neuron differentiation • GO:0072468 signal transduction • Wnt signaling pathway • T cell differentiation in thymus • non-canonical Wnt signaling pathway • canonical Wnt signaling pathway Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	8325	n/a
Ensembl	ENSG00000177283	n/a
UniProt	Q9H461	n/a
RefSeq (mRNA)	NM_031866	n/a
RefSeq (protein)	NP_114072	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn FZD8 yw FZD8 a elwir hefyd yn Frizzled class receptor 8 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 10, band 10p11.21.

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn FZD8.

• FZ-8
• hFZ8

Llyfryddiaeth

• "FZD8, a target of p53, promotes bone metastasis in prostate cancer by activating canonical Wnt/β-catenin signaling. ". Cancer Lett. 2017. PMID 28602974.
• "MicroRNA-100 suppresses the migration and invasion of breast cancer cells by targeting FZD-8 and inhibiting Wnt/β-catenin signaling pathway. ". Tumour Biol. 2016. PMID 26537584.
• "A pro-inflammatory role for the Frizzled-8 receptor in chronic bronchitis. ". Thorax. 2016. PMID 26797711.
• "Molecular model of the Wnt protein binding site on the surface of dimeric CRD domain of the hFzd8 receptor. ". Dokl Biochem Biophys. 2008. PMID 18505162.
• "Molecular cloning and characterization of human Frizzled-8 gene on chromosome 10p11.2.". Int J Oncol. 2001. PMID 11295046.