FUT8

FUT8
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 2DE0
Dynodwyr
Cyfenwau	FUT8, fucosyltransferase 8, CDGF, CDGF1
Dynodwyr allanol	OMIM: 602589 HomoloGene: 9650 GeneCards: FUT8
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • transferase activity • glycosyltransferase activity • SH3 domain binding • glycoprotein 6-alpha-L-fucosyltransferase activity • alpha-(1->6)-fucosyltransferase activity Cydrannau o'r gell • integral component of membrane • Golgi apparatus • bilen • Golgi membrane • Golgi cisterna membrane • extracellular exosome • cytosol Prosesau biolegol • GDP-L-fucose metabolic process • regulation of cellular response to oxidative stress • N-glycan fucosylation • N-glycan processing • in utero embryonic development • respiratory gaseous exchange by respiratory system • GO:0033578, GO:0033577, GO:0033575, GO:0033576 protein glycosylation • oligosaccharide biosynthetic process • regulation of gene expression • integrin-mediated signaling pathway • protein N-linked glycosylation • transforming growth factor beta receptor signaling pathway • cell migration • L-fucose catabolic process • receptor metabolic process • protein N-linked glycosylation via asparagine Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	2530	n/a
Ensembl	ENSG00000033170	n/a
UniProt	Q9BYC5	n/a
RefSeq (mRNA)	NM_004480 NM_178154 NM_178155 NM_178156 NM_178157 NM_001371533 NM_001371534 NM_001371536	n/a
RefSeq (protein)	NP_004471 NP_835368 NP_835369 NP_001358462 NP_001358463 NP_001358465	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn FUT8 yw FUT8 a elwir hefyd yn Alpha-(1,6)-fucosyltransferase a Fucosyltransferase 8 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 14, band 14q23.3.

Llyfryddiaeth

• "Revisiting the substrate specificity of mammalian α1,6-fucosyltransferase reveals that it catalyzes core fucosylation of N-glycans lacking α1,3-arm GlcNAc. ". J Biol Chem. 2017. PMID 28729420.
• "A Systems Biology Approach Identifies FUT8 as a Driver of Melanoma Metastasis. ". Cancer Cell. 2017. PMID 28609658.
• "Mammalian α-1,6-Fucosyltransferase (FUT8) Is the Sole Enzyme Responsible for the N-Acetylglucosaminyltransferase I-independent Core Fucosylation of High-mannose N-Glycans. ". J Biol Chem. 2016. PMID 27008861.
• "Fucosyltransferase 8 expression in breast cancer patients: A high throughput tissue microarray analysis. ". Histol Histopathol. 2016. PMID 26596733.
• "Expression of fucosyltransferase 8 is associated with an unfavorable clinical outcome in non-small cell lung cancers.". Oncology. 2015. PMID 25572677.