FRS2

FRS2
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 1XR0, 2MFQ
Dynodwyr
Cyfenwau	FRS2, FRS2A, FRS2alpha, SNT, SNT-1, SNT1, FRS1A, fibroblast growth factor receptor substrate 2
Dynodwyr allanol	OMIM: 607743 HomoloGene: 4846 GeneCards: FRS2
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • transmembrane receptor protein tyrosine kinase adaptor activity • fibroblast growth factor receptor binding • neurotrophin TRKA receptor binding • GO:0001948, GO:0016582 protein binding • phosphatase activator activity • 1-phosphatidylinositol-3-kinase activity • phosphatidylinositol-4,5-bisphosphate 3-kinase activity Cydrannau o'r gell • cytoplasm • endosome • bilen • Cellbilen • integral component of plasma membrane • endomembrane system • cell-cell junction • cytosol Prosesau biolegol • regulation of apoptotic process • G protein-coupled receptor signaling pathway • ventricular septum development • organ induction • transmembrane receptor protein tyrosine kinase signaling pathway • gastrulation with mouth forming second • MAPK cascade • lens placode formation involved in camera-type eye formation • fibroblast growth factor receptor signaling pathway • transmembrane receptor protein tyrosine phosphatase signaling pathway • lens development in camera-type eye • prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis • regulation of ERK1 and ERK2 cascade • neuroblast proliferation • forebrain development • regulation of epithelial cell proliferation • anterior/posterior axis specification, embryo • lens fiber cell development • phosphatidylinositol phosphate biosynthetic process • phosphatidylinositol-3-phosphate biosynthetic process • axon guidance • negative regulation of cardiac muscle cell differentiation • positive regulation of protein kinase B signaling • neurotrophin TRK receptor signaling pathway Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	10818	n/a
Ensembl	ENSG00000166225	n/a
UniProt	Q8WU20	n/a
RefSeq (mRNA)	NM_006654 NM_001042555 NM_001278351 NM_001278353 NM_001278354 NM_001278355 NM_001278356 NM_001278357	n/a
RefSeq (protein)	NP_001036020 NP_001265280 NP_001265282 NP_001265283 NP_001265284 NP_001265285 NP_001265286 NP_006645	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn FRS2 yw FRS2 a elwir hefyd yn Fibroblast growth factor receptor substrate 2 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 12, band 12q15.

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn FRS2.

• SNT
• SNT1
• FRS1A
• FRS2A
• SNT-1
• FRS2alpha

Llyfryddiaeth

• "FGF-receptor substrate 2 functions as a molecular sensor integrating external regulatory signals into the FGF pathway. ". Cell Res. 2009. PMID 19652666.
• "EGFR and FGFR signaling through FRS2 is subject to negative feedback control by ERK1/2. ". Biol Chem. 2003. PMID 12974390.
• "Hyperactivated FRS2α-mediated signaling in prostate cancer cells promotes tumor angiogenesis and predicts poor clinical outcome of patients. ". Oncogene. 2016. PMID 26096936.
• "The Tyrosine Kinase Adaptor Protein FRS2 Is Oncogenic and Amplified in High-Grade Serous Ovarian Cancer. ". Mol Cancer Res. 2015. PMID 25368431.
• "High-resolution genomic mapping reveals consistent amplification of the fibroblast growth factor receptor substrate 2 gene in well-differentiated and dedifferentiated liposarcoma.". Genes Chromosomes Cancer. 2011. PMID 21793095.