FRAT1

FRAT1
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 1GNG, 3ZRK, 3ZRL, 3ZRM, 4AFJ
Dynodwyr
Cyfenwau	FRAT1, WNT signaling pathway regulator, FRAT regulator of WNT signaling pathway 1
Dynodwyr allanol	OMIM: 602503 HomoloGene: 3999 GeneCards: FRAT1
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • GO:0001948, GO:0016582 protein binding Cydrannau o'r gell • cytosol • intracellular membrane-bounded organelle • cytoplasm Prosesau biolegol • Wnt signaling pathway • beta-catenin destruction complex disassembly • canonical Wnt signaling pathway • positive regulation of canonical Wnt signaling pathway Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	10023	n/a
Ensembl	ENSG00000165879	n/a
UniProt	Q92837	n/a
RefSeq (mRNA)	NM_181355 NM_005479	n/a
RefSeq (protein)	NP_005470	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn FRAT1 yw FRAT1 a elwir hefyd yn FRAT1, WNT signaling pathway regulator (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 10, band 10q24.1.

Llyfryddiaeth

• "Knockdown of FRAT1 expression by RNA interference inhibits human glioblastoma cell growth, migration and invasion. ". PLoS One. 2013. PMID 23613813.
• "Expression of Frat1 correlates with expression of β-catenin and is associated with a poor clinical outcome in human SCC and AC. ". Tumour Biol. 2012. PMID 22528942.
• "Knockdown of FRAT1 inhibits hypoxia-induced epithelial-to-mesenchymal transition via suppression of the Wnt/β-catenin pathway in hepatocellular carcinoma cells. ". Oncol Rep. 2016. PMID 27666874.
• "Frequently rearranged in advanced T‑cell lymphomas‑1 demonstrates oncogenic properties in prostate cancer. ". Mol Med Rep. 2016. PMID 27599661.
• "Overexpression of FRAT1 is associated with malignant phenotype and poor prognosis in human gliomas.". Dis Markers. 2015. PMID 25922553.