FOXK2

FOXK2
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 1JXS, 2C6Y
Dynodwyr
Cyfenwau	FOXK2, ILF, ILF-1, ILF1, forkhead box K2, nGTBP
Dynodwyr allanol	OMIM: 147685 HomoloGene: 18748 GeneCards: FOXK2
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • GO:0001131, GO:0001151, GO:0001130, GO:0001204 DNA-binding transcription factor activity • GO:0000980 RNA polymerase II cis-regulatory region sequence-specific DNA binding • sequence-specific DNA binding • DNA binding • GO:0001077, GO:0001212, GO:0001213, GO:0001211, GO:0001205 DNA-binding transcription activator activity, RNA polymerase II-specific • GO:0001948, GO:0016582 protein binding • magnesium ion binding • metal ion binding • GO:0001200, GO:0001133, GO:0001201 DNA-binding transcription factor activity, RNA polymerase II-specific • GO:0000975 transcription cis-regulatory region binding • GO:0001078, GO:0001214, GO:0001206 DNA-binding transcription repressor activity, RNA polymerase II-specific Cydrannau o'r gell • cnewyllyn cell • nucleoplasm • cytoplasm Prosesau biolegol • GO:0044324, GO:0003256, GO:1901213, GO:0046019, GO:0046020, GO:1900094, GO:0061216, GO:0060994, GO:1902064, GO:0003258, GO:0072212 regulation of transcription by RNA polymerase II • GO:0009373 regulation of transcription, DNA-templated • GO:0003257, GO:0010735, GO:1901228, GO:1900622, GO:1904488 positive regulation of transcription by RNA polymerase II • transcription, DNA-templated • transcription by RNA polymerase II • protein deubiquitination • anatomical structure morphogenesis • cell differentiation • GO:1901227 negative regulation of transcription by RNA polymerase II • cellular glucose homeostasis • negative regulation of autophagy • regulation of glucose metabolic process • response to starvation • GO:0045996 negative regulation of transcription, DNA-templated • GO:0060469, GO:0009371 positive regulation of transcription, DNA-templated • canonical glycolysis Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	3607	n/a
Ensembl	ENSG00000141568	n/a
UniProt	Q01167	n/a
RefSeq (mRNA)	NM_004514 NM_181430 NM_181431	n/a
RefSeq (protein)	NP_004505	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn FOXK2 yw FOXK2 a elwir hefyd yn Forkhead box K2 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 17, band 17q25.3.

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn FOXK2.

• ILF
• ILF1
• ILF-1

Llyfryddiaeth

• "FOXK2 transcription factor is a novel G/T-mismatch DNA binding protein. ". J Biochem. 2010. PMID 20097901.
• "FOXK2, regulted by miR-1271-5p, promotes cell growth and indicates unfavorable prognosis in hepatocellular carcinoma. ". Int J Biochem Cell Biol. 2017. PMID 28506857.
• "Foxk2 inhibits non-small cell lung cancer epithelial-mesenchymal transition and proliferation through the repression of different key target genes. ". Oncol Rep. 2017. PMID 28260088.
• "Sox9 mediated transcriptional activation of FOXK2 is critical for colorectal cancer cells proliferation. ". Biochem Biophys Res Commun. 2017. PMID 28007600.
• "The forkhead transcription factor FOXK2 promotes AP-1-mediated transcriptional regulation.". Mol Cell Biol. 2012. PMID 22083952.