FNTB

FNTB
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 1JCQ, 1LD7, 1LD8, 1MZC, 1S63, 1SA4, 1TN6, 2F0Y, 2H6F, 2H6G, 2H6H, 2H6I, 2IEJ, 3E37
Dynodwyr
Cyfenwau	FNTB, FPTB, farnesyltransferase, CAAX box, beta
Dynodwyr allanol	OMIM: 134636 HomoloGene: 1535 GeneCards: FNTB
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • metal ion binding • transferase activity • prenyltransferase activity • catalytic activity • protein farnesyltransferase activity • GO:0001948, GO:0016582 protein binding • farnesyltranstransferase activity • zinc ion binding • isoprenoid binding • peptide binding Cydrannau o'r gell • cytosol • protein farnesyltransferase complex • microtubule associated complex • GO:0009327 protein-containing complex Prosesau biolegol • protein farnesylation • positive regulation of cell population proliferation • negative regulation of cell population proliferation • response to inorganic substance • GO:1904578 response to organic cyclic compound • response to cytokine • wound healing • positive regulation of cell cycle • positive regulation of fibroblast proliferation • positive regulation of nitric-oxide synthase biosynthetic process • protein prenylation • regulation of fibroblast proliferation • regulation of rhodopsin mediated signaling pathway Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	2342	n/a
Ensembl	n/a	n/a
UniProt	P49356	n/a
RefSeq (mRNA)	NM_002028	n/a
RefSeq (protein)	NP_002019 NP_001189487 NP_001189488	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn FNTB yw FNTB a elwir hefyd yn Farnesyltransferase, CAAX box, beta (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 14, band 14q23.3.

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn FNTB.

• FPTB

Llyfryddiaeth

• "Farnesyltransferase inhibitor attenuates methamphetamine toxicity-induced Ras proteins activation and cell death in neuroblastoma SH-SY5Y cells. ". Neurosci Lett. 2013. PMID 23643986.
• "Expansion of protein farnesyltransferase specificity using "tunable" active site interactions: development of bioengineered prenylation pathways. ". J Biol Chem. 2012. PMID 22992747.
• "Expression of farnesyltransferase in primary liver cancer. ". Chin Med J (Engl). 2012. PMID 22882915.
• "Evaluation of farnesyl:protein transferase and geranylgeranyl:protein transferase inhibitor combinations in preclinical models. ". Cancer Res. 2001. PMID 11751396.
• "Dual protein farnesyltransferase-geranylgeranyltransferase-I inhibitors as potential cancer chemotherapeutic agents.". J Med Chem. 2003. PMID 12825937.