FLT3LG

FLT3LG
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 1ETE, 3QS7, 3QS9
Dynodwyr
Cyfenwau	FLT3LG, FL, FLT3L, fms related tyrosine kinase 3 ligand, FLG3L, fms related receptor tyrosine kinase 3 ligand
Dynodwyr allanol	OMIM: 600007 HomoloGene: 48021 GeneCards: FLT3LG
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • cytokine activity • protein homodimerization activity • receptor tyrosine kinase binding • signaling receptor binding • 1-phosphatidylinositol-3-kinase activity Cydrannau o'r gell • integral component of membrane • bilen • intrinsic component of external side of plasma membrane • Cellbilen • cell surface • extracellular region • extracellular space • intracellular anatomical structure Prosesau biolegol • positive regulation of protein phosphorylation • positive regulation of natural killer cell differentiation • lymphocyte differentiation • positive regulation of cell proliferation in bone marrow • negative regulation of apoptotic process in bone marrow cell • positive regulation of myoblast fusion • positive regulation of cell cycle • positive regulation of myoblast differentiation • positive regulation of cell population proliferation • embryonic hemopoiesis • homeostasis of number of cells within a tissue • regulation of myeloid dendritic cell activation • GO:0072468 signal transduction • GO:0003257, GO:0010735, GO:1901228, GO:1900622, GO:1904488 positive regulation of transcription by RNA polymerase II • positive regulation of osteoclast proliferation • regulation of signaling receptor activity • cytokine-mediated signaling pathway • positive regulation of natural killer cell proliferation • MAPK cascade • phosphatidylinositol-3-phosphate biosynthetic process Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	2323	n/a
Ensembl	ENSG00000090554	n/a
UniProt	P49771	n/a
RefSeq (mRNA)	NM_001204502 NM_001204503 NM_001278637 NM_001278638 NM_001459	n/a
RefSeq (protein)	NP_001191431 NP_001191432 NP_001265566 NP_001265567 NP_001450 NP_001191431.1	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn FLT3LG yw FLT3LG a elwir hefyd yn Fms related tyrosine kinase 3 ligand (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 19, band 19q13.33.

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn FLT3LG.

• FL
• FLG3L
• FLT3L

Llyfryddiaeth

• "Co-expression of wild-type FLT3 attenuates the inhibitory effect of FLT3 inhibitor on FLT3 mutated leukemia cells. ". Oncotarget. 2016. PMID 27331411.
• "Serum concentrations of Flt-3 ligand in rheumatic diseases. ". Biosci Trends. 2015. PMID 26559027.
• "Human bone marrow stromal cells simultaneously support B and T/NK lineage development from human haematopoietic progenitors: a principal role for flt3 ligand in lymphopoiesis. ". Br J Haematol. 2012. PMID 22463758.
• "FLT3 ligand impedes the efficacy of FLT3 inhibitors in vitro and in vivo. ". Blood. 2011. PMID 21263155.
• "Human Flt3L generates dendritic cells from canine peripheral blood precursors: implications for a dog glioma clinical trial.". PLoS One. 2010. PMID 20552015.