FLOT2

FLOT2
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 1WIN
Dynodwyr
Cyfenwau	FLOT2, ECS-1, ECS1, ESA, ESA1, M17S1, flotillin 2
Dynodwyr allanol	OMIM: 131560 HomoloGene: 3293 GeneCards: FLOT2
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • protease binding • GO:0001948, GO:0016582 protein binding • protein heterodimerization activity • ionotropic glutamate receptor binding Cydrannau o'r gell • fesigl • endosome • bilen • cell-cell contact zone • focal adhesion • endocytic vesicle • acrosomal membrane • flotillin complex • uropod • basolateral plasma membrane • apical plasma membrane • cortical actin cytoskeleton • perinuclear region of cytoplasm • caveola • membrane raft • extracellular exosome • GO:0016023 cytoplasmic vesicle • lamellipodium • Cellbilen • dendrite cytoplasm • synapse • glutamatergic synapse • anchored component of presynaptic active zone membrane Prosesau biolegol • positive regulation of establishment of T cell polarity • regulation of toll-like receptor 3 signaling pathway • regulation of heterotypic cell-cell adhesion • protein stabilization • negative regulation of amyloid precursor protein catabolic process • negative regulation of gene expression • protein localization to plasma membrane raft • cell adhesion • membrane raft assembly • regulation of myoblast differentiation • epidermis development • protein localization to plasma membrane • anterograde dendritic transport • regulation of postsynaptic membrane neurotransmitter receptor levels • positive regulation of NF-kappaB transcription factor activity Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	2319	n/a
Ensembl	ENSG00000132589	n/a
UniProt	Q14254	n/a
RefSeq (mRNA)	NM_004475 NM_001330170	n/a
RefSeq (protein)	NP_001317099 NP_004466	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn FLOT2 yw FLOT2 a elwir hefyd yn Flotillin 2 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 17, band 17q11.2.

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn FLOT2.

• ESA
• ECS1
• ESA1
• ECS-1
• M17S1

Llyfryddiaeth

• "Up-regulation of Flot-2 protein is related to lymph node metastasis and poor prognosis in human solid tumors. ". Minerva Chir. 2017. PMID 27981826.
• "Flotillin-2 Gene Is Associated with Coronary Artery Disease in Chinese Han Population. ". Genet Test Mol Biomarkers. 2015. PMID 26556629.
• "FLOT-2 is an independent prognostic marker in oral squamous cell carcinoma. ". Int J Clin Exp Pathol. 2015. PMID 26339392.
• "Flotillin-2 promotes nasopharyngeal carcinoma metastasis and is necessary for the epithelial-mesenchymal transition induced by transforming growth factor-β. ". Oncotarget. 2015. PMID 25909165.
• "High expression of flotillin-2 is associated with poor clinical survival in cervical carcinoma.". Int J Clin Exp Pathol. 2015. PMID 25755754.