FKBP8

FKBP8
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 2AWG, 2D9F, 2F2D, 2MF9, 3EY6
Dynodwyr
Cyfenwau	FKBP8, FKBP38, FKBPr38, FK506 binding protein 8, FKBP prolyl isomerase 8
Dynodwyr allanol	OMIM: 604840 HomoloGene: 7720 GeneCards: FKBP8
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • FK506 binding • isomerase activity • peptidyl-prolyl cis-trans isomerase activity • metal ion binding • GO:0001948, GO:0016582 protein binding • identical protein binding • disordered domain specific binding Cydrannau o'r gell • integral component of membrane • bilen • mitochondrial membranes • integral component of endoplasmic reticulum membrane • mitochondrial envelope • mitocondria • Reticwlwm endoplasmig • cytosol • cytoplasm • GO:0009327 protein-containing complex Prosesau biolegol • GO:0097285 apoptotic process • GO:0007243 intracellular signal transduction • multicellular organism growth • cell fate specification • negative regulation of apoptotic process • regulation of BMP signaling pathway • neural tube development • positive regulation of BMP signaling pathway • regulation of gene expression • smoothened signaling pathway • camera-type eye development • dorsal/ventral neural tube patterning • GO:0022415 viral process • dorsal/ventral pattern formation • chaperone-mediated protein folding • protein peptidyl-prolyl isomerization • GO:0033128 negative regulation of protein phosphorylation Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	23770	n/a
Ensembl	ENSG00000105701	n/a
UniProt	Q14318	n/a
RefSeq (mRNA)	NM_001308373 NM_012181	n/a
RefSeq (protein)	NP_001295302 NP_036313 NP_001295302.1	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn FKBP8 yw FKBP8 a elwir hefyd yn Peptidyl-prolyl cis-trans isomerase FKBP8 a FK506 binding protein 8, 38kDa, isoform CRA_a (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 19, band 19p13.11.

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn FKBP8.

• FKBP38
• FKBPr38

Llyfryddiaeth

• "New structural aspects of FKBP38 activation. ". Biol Chem. 2010. PMID 20707607.
• "Characterization of a Bcl-XL-interacting protein FKBP8 and its splice variant in human RPE cells. ". Invest Ophthalmol Vis Sci. 2008. PMID 18385096.
• "The structure of FKBP38 in complex with the MEEVD tetratricopeptide binding-motif of Hsp90. ". PLoS One. 2017. PMID 28278223.
• "Functional role of the flexible N-terminal extension of FKBP38 in catalysis. ". Sci Rep. 2013. PMID 24145868.
• "Phosphatidic acid activates mammalian target of rapamycin complex 1 (mTORC1) kinase by displacing FK506 binding protein 38 (FKBP38) and exerting an allosteric effect.". J Biol Chem. 2011. PMID 21737445.