FKBP4

FKBP4
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 1N1A, 1P5Q, 1Q1C, 1QZ2, 4DRJ, 4LAV, 4LAW, 4LAX, 4LAY, 4TW8
Dynodwyr
Cyfenwau	FKBP4, FKBP51, FKBP52, FKBP59, HBI, Hsp56, PPIase, p52, FK506 binding protein 4, FKBP prolyl isomerase 4
Dynodwyr allanol	OMIM: 600611 HomoloGene: 36085 GeneCards: FKBP4
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • protein-macromolecule adaptor activity • heat shock protein binding • copper-dependent protein binding • FK506 binding • GTP binding • isomerase activity • peptidyl-prolyl cis-trans isomerase activity • phosphoprotein binding • GO:0001948, GO:0016582 protein binding • glucocorticoid receptor binding • tau protein binding • ATP binding • RNA binding Cydrannau o'r gell • cell projection • axonal growth cone • nucleoplasm • axon • neuronal cell body • mitocondria • perinuclear region of cytoplasm • neuron projection • microtubule • extracellular exosome • Cytosgerbwd • cnewyllyn cell • cytoplasm • cytosol • GO:0009327 protein-containing complex Prosesau biolegol • androgen receptor signaling pathway • negative regulation of neuron projection development • negative regulation of microtubule polymerization • prostate gland development • protein peptidyl-prolyl isomerization • reproductive structure development • male sex differentiation • negative regulation of microtubule polymerization or depolymerization • regulation of cellular response to heat • protein-containing complex localization • copper ion transport • steroid hormone receptor complex assembly • embryo implantation • chaperone-mediated protein folding • protein folding Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	2288	n/a
Ensembl	ENSG00000004478	n/a
UniProt	Q02790	n/a
RefSeq (mRNA)	NM_002014	n/a
RefSeq (protein)	NP_002005	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn FKBP4 yw FKBP4 a elwir hefyd yn FK506 binding protein 4 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 12, band 12p13.33.

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn FKBP4.

• HBI
• p52
• Hsp56
• FKBP51
• FKBP52
• FKBP59
• PPIase

Llyfryddiaeth

• "Hsp90-binding immunophilin FKBP52 modulates telomerase activity by promoting the cytoplasmic retrotransport of hTERT. ". Biochem J. 2016. PMID 27503910.
• "Caspase-cleaved Tau-D(421) is colocalized with the immunophilin FKBP52 in the autophagy-endolysosomal system of Alzheimer's disease neurons. ". Neurobiol Aging. 2016. PMID 27479154.
• "The FKBP52 Cochaperone Acts in Synergy with β-Catenin to Potentiate Androgen Receptor Signaling. ". PLoS One. 2015. PMID 26207810.
• "Expression of 52-kDa FK506-binding protein (FKBP52) in human placenta complicated by preeclampsia and intrauterine growth restriction. ". Anal Quant Cytopathol Histpathol. 2015. PMID 26065228.
• "Therapeutic Targeting of the FKBP52 Co-Chaperone in Steroid Hormone Receptor-Regulated Physiology and Disease.". Curr Mol Pharmacol. 2015. PMID 25986565.