FKBP1B

FKBP1B
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 1C9H, 3J8E, 4C02, 4IQ2, 4IQC
Dynodwyr
Cyfenwau	FKBP1B, FKBP12.6, FKBP1L, OTK4, PKBP1L, PPIase, FK506 binding protein 1B, FKBP prolyl isomerase 1B
Dynodwyr allanol	OMIM: 600620 HomoloGene: 68380 GeneCards: FKBP1B
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • ryanodine-sensitive calcium-release channel activity • calcium channel inhibitor activity • transmembrane transporter binding • FK506 binding • isomerase activity • peptidyl-prolyl cis-trans isomerase activity • GO:0001948, GO:0016582 protein binding • signaling receptor binding • cyclic nucleotide binding Cydrannau o'r gell • cytoplasm • calcium channel complex • intracellular membrane-bounded organelle • bilen • sarcoplasmic reticulum • Z disc • sarcoplasmic reticulum membrane • cytosol Prosesau biolegol • smooth muscle contraction • regulation of ryanodine-sensitive calcium-release channel activity • release of sequestered calcium ion into cytosol • regulation of cardiac conduction • release of sequestered calcium ion into cytosol by sarcoplasmic reticulum • regulation of cytosolic calcium ion concentration • regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion • positive regulation of cytosolic calcium ion concentration • cell communication by electrical coupling involved in cardiac conduction • negative regulation of insulin secretion involved in cellular response to glucose stimulus • insulin secretion • response to glucose • positive regulation of axon regeneration • protein maturation by protein folding • response to organic substance • negative regulation of heart rate • response to vitamin E • regulation of heart rate • negative regulation of ryanodine-sensitive calcium-release channel activity • response to redox state • T cell proliferation • cludo transmembrane rhwng ïonau • positive regulation of sequestering of calcium ion • neuronal action potential propagation • protein refolding • negative regulation of release of sequestered calcium ion into cytosol • regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum • 'de novo' protein folding • calcium-mediated signaling using intracellular calcium source • response to hydrogen peroxide • chaperone-mediated protein folding • protein peptidyl-prolyl isomerization • negative regulation of phosphoprotein phosphatase activity Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	2281	n/a
Ensembl	ENSG00000119782	n/a
UniProt	P68106	n/a
RefSeq (mRNA)	NM_004116 NM_054033 NM_001322963 NM_001322964	n/a
RefSeq (protein)	NP_001309892 NP_001309893 NP_004107 NP_473374	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn FKBP1B yw FKBP1B a elwir hefyd yn FK506 binding protein 1B (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 2, band 2p23.3.

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn FKBP1B.

• OTK4
• FKBP1L
• PKBP1L
• PPIase
• FKBP12.6

Llyfryddiaeth

• "Total chemical synthesis, refolding, and crystallographic structure of fully active immunophilin calstabin 2 (FKBP12.6). ". Protein Sci. 2016. PMID 27670942.
• "Mapping the ryanodine receptor FK506-binding protein subunit using fluorescence resonance energy transfer. ". J Biol Chem. 2010. PMID 20404344.
• "Enhancing calstabin binding to ryanodine receptors improves cardiac and skeletal muscle function in heart failure. ". Proc Natl Acad Sci U S A. 2005. PMID 15972811.
• "Structure of FKBP12.6 in complex with rapamycin. ". Acta Crystallogr D Biol Crystallogr. 2000. PMID 10713512.
• "Molecular cloning and expression of a novel human gene that is highly homologous to human FK506-binding protein 12kDa (hFKBP-12) and characterization of two alternatively spliced transcripts.". Biochem Biophys Res Commun. 1994. PMID 7513996.