FHL1

FHL1
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 1X63, 2CUP, 2CUR
Dynodwyr
Cyfenwau	FHL1, FHL-1, FHL1A, FHL1B, FLH1A, KYOT, SLIM, SLIM-1, SLIM1, SLIMMER, XMPMA, RBMX1A, RBMX1B, four and a half LIM domains 1, FCMSU
Dynodwyr allanol	OMIM: 300163 HomoloGene: 31038 GeneCards: FHL1
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • GO:0001948, GO:0016582 protein binding • transmembrane transporter binding • metal ion binding • molecular function Cydrannau o'r gell • cytoplasm • Cellbilen • cnewyllyn cell • focal adhesion • cytosol Prosesau biolegol • animal organ morphogenesis • GO:1990376 negative regulation of G1/S transition of mitotic cell cycle • multicellular organism development • cell differentiation • muscle organ development • negative regulation of cell growth • regulation of potassium ion transmembrane transporter activity • regulation of membrane depolarization • negative regulation of G2/M transition of mitotic cell cycle • positive regulation of potassium ion transport Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	2273	n/a
Ensembl	ENSG00000022267	n/a
UniProt	Q13642 Q5JXH9	n/a
RefSeq (mRNA)	NM_001159699 NM_001159700 NM_001159701 NM_001159702 NM_001159703 NM_001159704 NM_001167819 NM_001449 NM_001330659 NM_001369326 NM_001369327 NM_001369328 NM_001369329 NM_001369330 NM_001369331	n/a
RefSeq (protein)	NP_001153171 NP_001153172 NP_001153173 NP_001153174 NP_001153175 NP_001153176 NP_001161291 NP_001317588 NP_001440 NP_001356255 NP_001356256 NP_001356257 NP_001356258 NP_001356259 NP_001356260	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn FHL1 yw FHL1 a elwir hefyd yn Four and a half LIM domains protein 1 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom X dynol, band Xq26.3.

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn FHL1.

• KYOT
• SLIM
• FCMSU
• FHL-1
• FHL1A
• FHL1B
• FLH1A
• SLIM1
• XMPMA
• RBMX1A
• RBMX1B
• SLIM-1
• SLIMMER

Llyfryddiaeth

• "Exome Sequencing Identified a Splice Site Mutation in FHL1 that Causes Uruguay Syndrome, an X-Linked Disorder With Skeletal Muscle Hypertrophy and Premature Cardiac Death. ". Circ Cardiovasc Genet. 2016. PMID 26933038.
• "X-linked FHL1 as a novel therapeutic target for head and neck squamous cell carcinoma. ". Oncotarget. 2016. PMID 26908444.
• "Unclassifiable arrhythmic cardiomyopathy associated with Emery-Dreifuss caused by a mutation in FHL1. ". Clin Genet. 2016. PMID 26857240.
• "Development of autoantibodies against muscle-specific FHL1 in severe inflammatory myopathies. ". J Clin Invest. 2015. PMID 26551678.
• "[FHL1 knockdown mediated by lentiviral shRNA promotes the growth of HeLa and HepG2 cells].". Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi. 2015. PMID 26146054.