FHIT

FHIT
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 1FHI, 2FHI, 2FIT, 5FIT, 3FIT, 1FIT, 4FIT, 6FIT
Dynodwyr
Cyfenwau	FHIT, AP3Aase, FRA3B, fragile histidine triad, tríada histidina fràgil, fragile histidine triad diadenosine triphosphatase
Dynodwyr allanol	OMIM: 601153 HomoloGene: 21661 GeneCards: FHIT
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • bis(5'-adenosyl)-triphosphatase activity • nucleotide binding • catalytic activity • hydrolase activity • GO:0001948, GO:0016582 protein binding • ubiquitin protein ligase binding • identical protein binding Cydrannau o'r gell • cytoplasm • cytosol • mitocondria • cnewyllyn cell • fibrillar center • Cellbilen Prosesau biolegol • negative regulation of proteasomal ubiquitin-dependent protein catabolic process • purine nucleotide metabolic process • GO:0009373 regulation of transcription, DNA-templated • nucleotide metabolic process • transcription, DNA-templated • intrinsic apoptotic signaling pathway by p53 class mediator • GO:0097285 apoptotic process Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	2272	n/a
Ensembl	ENSG00000189283	n/a
UniProt	P49789	n/a
RefSeq (mRNA)	NM_001166243 NM_002012 NM_001320899 NM_001320900 NM_001320901 NM_001354589 NM_001354590	n/a
RefSeq (protein)	NP_001159715 NP_001307828 NP_001307829 NP_001307830 NP_002003 NP_001341518 NP_001341519	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn FHIT yw FHIT a elwir hefyd yn Fragile histidine triad (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 3, band 3p14.2.

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn FHIT.

• FRA3B
• AP3Aase

Llyfryddiaeth

• "Reduction in the copy number and expression level of the recurrent human papillomavirus integration gene fragile histidine triad (FHIT) predicts the transition of cervical lesions. ". PLoS One. 2017. PMID 28414756.
• "Fhit down-regulation is an early event in pancreatic carcinogenesis. ". Virchows Arch. 2017. PMID 28289900.
• "New interactions between tumor suppressor Fhit protein and a nonhydrolyzable analog of its AP4 A substrate. ". FEBS Lett. 2017. PMID 28094435.
• "FHIT promoter methylation status, low protein and high mRNA levels in patients with non-small cell lung cancer. ". Int J Oncol. 2016. PMID 27572663.
• "Expression and clinical significance of miRNAs that may be associated with the FHIT gene in breast cancer.". Gene. 2016. PMID 27236032.