FGG

FGG
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 1DUG, 1FIB, 1FIC, 1FID, 1FZA, 1FZB, 1FZC, 1FZE, 1FZF, 1FZG, 1LT9, 1LTJ, 1N86, 1N8E, 1RE3, 1RE4, 1RF0, 1RF1, 2A45, 2FFD, 2FIB, 2H43, 2HLO, 2HOD, 2HPC, 2HWL, 2OYH, 2OYI, 2Q9I, 2VDO, 2VDP, 2VDQ, 2VDR, 2VR3, 2XNX, 2XNY, 2Y7L, 2Z4E, 3BVH, 3E1I, 3FIB, 3GHG, 3H32, 3HUS, 4B60
Dynodwyr
Cyfenwau	FGG, fibrinogen gamma chain
Dynodwyr allanol	OMIM: 134850 HomoloGene: 429 GeneCards: FGG
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • protein-macromolecule adaptor activity • structural molecule activity • metal ion binding • GO:0001948, GO:0016582 protein binding • signaling receptor binding • cell adhesion molecule binding • protein homodimerization activity • extracellular matrix structural constituent Cydrannau o'r gell • cytoplasm • platelet alpha granule • blood microparticle • Cellbilen • fibrinogen complex • extracellular region • cell surface • extracellular exosome • platelet alpha granule lumen • external side of plasma membrane • extracellular space • endoplasmic reticulum lumen • collagen-containing extracellular matrix Prosesau biolegol • hemostasis • negative regulation of endothelial cell apoptotic process • positive regulation of peptide hormone secretion • protein polymerization • positive regulation of heterotypic cell-cell adhesion • fibrinolysis • platelet degranulation • blood coagulation • extracellular matrix organization • protein secretion • response to calcium ion • positive regulation of substrate adhesion-dependent cell spreading • negative regulation of extrinsic apoptotic signaling pathway via death domain receptors • positive regulation of vasoconstriction • positive regulation of protein secretion • positive regulation of ERK1 and ERK2 cascade • positive regulation of exocytosis • blood coagulation, fibrin clot formation • plasminogen activation • cell-matrix adhesion • platelet aggregation • GO:0072468 signal transduction • platelet activation • toll-like receptor signaling pathway • platelet maturation • cellular response to interleukin-1 • cellular response to interleukin-6 • negative regulation of platelet aggregation • post-translational protein modification Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	2266	n/a
Ensembl	ENSG00000171557	n/a
UniProt	P02679	n/a
RefSeq (mRNA)	NM_021870 NM_000509	n/a
RefSeq (protein)	NP_000500 NP_068656	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn FGG yw FGG a elwir hefyd yn Fibrinogen gamma chain (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 4, band 4q32.1.

Llyfryddiaeth

• "The amplitude of coagulation curves from thrombin time tests allows dysfibrinogenemia caused by the common mutation FGG-Arg301 to be distinguished from hypofibrinogenemia. ". Int J Lab Hematol. 2017. PMID 28318107.
• "Lack of association of plasma gamma prime (γ') fibrinogen with incident cardiovascular disease. ". Thromb Res. 2016. PMID 27180117.
• "[Analysis of a family with congenital dysfibrinogenemia caused by an Arg275His mutation in the gamma chain of fibrinogen]. ". Zhonghua Yi Xue Yi Chuan Xue Za Zhi. 2016. PMID 27060305.
• "Prospective study of γ' fibrinogen and incident venous thromboembolism: The Longitudinal Investigation of Thromboembolism Etiology (LITE). ". Thromb Res. 2016. PMID 26916295.
• "[Analysis of molecular pathogenesis and clinical phenotypes in 10 probands with inherited fibrinogen deficiency].". Zhonghua Yi Xue Yi Chuan Xue Za Zhi. 2015. PMID 26663050.