FGFR3

FGFR3
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 1RY7, 2LZL, 4K33
Dynodwyr
Cyfenwau	FGFR3, ACH, CD333, CEK2, HSFGFR3EX, JTK4, fibroblast growth factor receptor 3
Dynodwyr allanol	OMIM: 134934 HomoloGene: 55437 GeneCards: FGFR3
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • transferase activity • nucleotide binding • protein kinase activity • kinase activity • GO:0001948, GO:0016582 protein binding • transmembrane receptor protein tyrosine kinase activity • fibroblast growth factor binding • fibroblast growth factor-activated receptor activity • ATP binding • protein tyrosine kinase activity • phosphatidylinositol-4,5-bisphosphate 3-kinase activity • 1-phosphatidylinositol-3-kinase activity • identical protein binding • receptor tyrosine kinase • transmembrane signaling receptor activity Cydrannau o'r gell • cytoplasm • integral component of membrane • Golgi apparatus • bilen • focal adhesion • Cellbilen • integral component of plasma membrane • transport vesicle • extracellular region • cell surface • Reticwlwm endoplasmig • GO:0016023 cytoplasmic vesicle • cnewyllyn cell • receptor complex Prosesau biolegol • bone mineralization • chondrocyte differentiation • phosphorylation • negative regulation of developmental growth • cell-cell signaling • bone morphogenesis • endochondral ossification • bone maturation • fibroblast growth factor receptor apoptotic signaling pathway • MAPK cascade • positive regulation of phosphatidylinositol 3-kinase activity • positive regulation of phospholipase activity • fibroblast growth factor receptor signaling pathway • protein phosphorylation • chondrocyte proliferation • positive regulation of cell population proliferation • positive regulation of ERK1 and ERK2 cascade • protein autophosphorylation • peptidyl-tyrosine phosphorylation • endochondral bone growth • positive regulation of MAPK cascade • GO:0097285 apoptotic process • phosphatidylinositol phosphate biosynthetic process • phosphatidylinositol-3-phosphate biosynthetic process • positive regulation of tyrosine phosphorylation of STAT protein • skeletal system development • positive regulation of protein kinase B signaling • negative regulation of signal transduction • cell differentiation • negative regulation of apoptotic process • transmembrane receptor protein tyrosine kinase signaling pathway Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	2261	n/a
Ensembl	ENSG00000068078	n/a
UniProt	P22607	n/a
RefSeq (mRNA)	NM_000142 NM_001163213 NM_022965 NM_001354809 NM_001354810	n/a
RefSeq (protein)	NP_000133 NP_001156685 NP_075254 NP_001341738 NP_001341739	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn FGFR3 yw FGFR3 a elwir hefyd yn Fibroblast growth factor receptor 3 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 4, band 4p16.3.

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn FGFR3.

• ACH
• CEK2
• JTK4
• CD333
• HSFGFR3EX

Llyfryddiaeth

• "Identification of a novel mutation in the FGFR3 gene in a Chinese family with Hypochondroplasia. ". Gene. 2018. PMID 29080836.
• "[Rapid detection of hot spot mutations of FGFR3 gene with PCR-high resolution melting assay]. ". Zhonghua Yi Xue Yi Chuan Xue Za Zhi. 2017. PMID 28777845.
• "Kinase Activity of Fibroblast Growth Factor Receptor 3 Regulates Activity of the Papillomavirus E2 Protein. ". J Virol. 2017. PMID 28768864.
• "Mutation Detection of Fibroblast Growth Factor Receptor 3 for Infiltrative Hepatocellular Carcinoma by Whole-Exome Sequencing. ". Dig Dis Sci. 2017. PMID 28058595.
• "Drug-sensitive FGFR3 mutations in lung adenocarcinoma.". Ann Oncol. 2017. PMID 27998968.