FGF12

FGF12
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 1Q1U, 4JQ0
Dynodwyr
Cyfenwau	FGF12, FGF12B, FHF1, fibroblast growth factor 12, EIEE47, DEE47
Dynodwyr allanol	OMIM: 601513 HomoloGene: 10874 GeneCards: FGF12
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • sodium channel regulator activity • heparin binding • transmembrane transporter binding • fibroblast growth factor receptor binding • GO:0001948, GO:0016582 protein binding • growth factor activity Cydrannau o'r gell • cnewyllyn cell • intracellular anatomical structure • extracellular space Prosesau biolegol • negative regulation of cation channel activity • adult locomotory behavior • cell-cell signaling • cardiac muscle cell action potential involved in contraction • regulation of membrane depolarization • nervous system development • fibroblast growth factor receptor signaling pathway • JNK cascade • heart development • neuromuscular process • regulation of sodium ion transmembrane transporter activity • GO:0061423 positive regulation of sodium ion transport • regulation of sodium ion transmembrane transport • GO:0072468 signal transduction • chemical synaptic transmission • regulation of voltage-gated sodium channel activity • regulation of neuronal action potential • regulation of signaling receptor activity Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	2257	n/a
Ensembl	ENSG00000114279	n/a
UniProt	P61328	n/a
RefSeq (mRNA)	NM_004113 NM_021032 NM_001377292 NM_001377293 NM_001377294	n/a
RefSeq (protein)	NP_004104 NP_066360 NP_001364221 NP_001364222 NP_001364223	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn FGF12 yw FGF12 a elwir hefyd yn Fibroblast growth factor 12 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 3, band 3q28-q29.

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn FGF12.

• FHF1
• EIEE47
• FGF12B

Llyfryddiaeth

• "Exome sequencing identified FGF12 as a novel candidate gene for Kashin-Beck disease. ". Funct Integr Genomics. 2016. PMID 26290467.
• "FGF12 is a candidate Brugada syndrome locus. ". Heart Rhythm. 2013. PMID 24096171.
• "Fibroblast growth factor-12 (FGF12) translocation into intestinal epithelial cells is dependent on a novel cell-penetrating peptide domain: involvement of internalization in the in vivo role of exogenous FGF12. ". J Biol Chem. 2011. PMID 21518765.
• "Involvement of intracellular expression of FGF12 in radiation-induced apoptosis in mast cells. ". J Radiat Res. 2008. PMID 18525161.
• "Biophysical characterization of fibroblast growth factor homologous factor-1b (FHF-1b): sodium dodecyl sulfate promotes two state folding.". Protein Pept Lett. 2008. PMID 18289114.