FGF1

FGF1
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 4QO3, 1AXM, 1DJS, 1DZC, 1DZD, 1E0O, 1EVT, 1HKN, 1JQZ, 1JT3, 1JT4, 1JT5, 1JT7, 1JTC, 1JY0, 1K5U, 1K5V, 1M16, 1NZK, 1P63, 1PZZ, 1Q03, 1Q04, 1RG8, 1RML, 1RY7, 1YTO, 1Z2V, 1Z4S, 2AFG, 2AQZ, 2AXM, 2ERM, 2HW9, 2HWA, 2HWM, 2HZ9, 2K43, 2K4A, 2K8R, 2KI4, 2KI6, 2NTD, 2Q9X, 2RQ9, 3B9U, 3BA4, 3BA5, 3BA7, 3BAD, 3BAG, 3BAH, 3BAO, 3BAQ, 3BAU, 3BAV, 3BB2, 3CQA, 3CRG, 3CRH, 3CRI, 3CU1, 3FGM, 3FJ8, 3FJ9, 3FJA, 3FJB, 3FJC, 3FJD, 3FJE, 3FJF, 3FJH, 3FJI, 3FJJ, 3FJK, 3HOM, 3JUT, 3K1X, 3O3Q, 3OJ2, 3OJM, 3OJV, 3UD7, 3UD8, 3UD9, 3UDA, 4J23, 4Q91, 4Q9G, 4Q9P, 4QAL, 4QBC, 4QBV, 4QC4, 4XKI, 4YOL
Dynodwyr
Cyfenwau	FGF1, AFGF, ECGF, ECGF-beta, ECGFA, ECGFB, FGF-1, FGF-alpha, FGFA, GLIO703, HBGF-1, HBGF1, fibroblast growth factor 1
Dynodwyr allanol	OMIM: 131220 HomoloGene: 625 GeneCards: FGF1
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • S100 protein binding • GO:0001948, GO:0016582 protein binding • growth factor activity • protein tyrosine kinase activity • phosphatidylinositol-4,5-bisphosphate 3-kinase activity • fibroblast growth factor receptor binding • integrin binding • 1-phosphatidylinositol-3-kinase activity • heparin binding • Hsp70 protein binding Cydrannau o'r gell • cytoplasm • cytosol • extracellular region • cell cortex • nucleolus • cnewyllyn cell • extracellular space • GO:0005578 extracellular matrix Prosesau biolegol • cell differentiation • cellular response to heat • positive regulation of protein phosphorylation • positive regulation of MAP kinase activity • organ induction • lung development • positive regulation of epithelial cell proliferation • anatomical structure morphogenesis • GO:0010740 positive regulation of intracellular signal transduction • branch elongation involved in ureteric bud branching • positive regulation of angiogenesis • MAPK cascade • multicellular organism development • mesonephric epithelium development • angiogenesis • regulation of endothelial cell chemotaxis to fibroblast growth factor • positive regulation of cholesterol biosynthetic process • cell population proliferation • positive regulation of cell division • GO:0003257, GO:0010735, GO:1901228, GO:1900622, GO:1904488 positive regulation of transcription by RNA polymerase II • GO:0072468 signal transduction • phosphatidylinositol phosphate biosynthetic process • peptidyl-tyrosine phosphorylation • positive regulation of sprouting angiogenesis • fibroblast growth factor receptor signaling pathway • positive regulation of cell population proliferation • phosphatidylinositol-3-phosphate biosynthetic process • regulation of endothelial tube morphogenesis • positive regulation of cell migration • positive regulation of endothelial cell migration • activation of protein kinase B activity • regulation of signaling receptor activity • positive regulation of protein kinase B signaling Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	2246	n/a
Ensembl	ENSG00000113578	n/a
UniProt	P05230	n/a
RefSeq (mRNA)	NM_000800 NM_001144892 NM_001144934 NM_001144935 NM_001257205 NM_001257206 NM_001257207 NM_001257208 NM_001257209 NM_001257210 NM_001257211 NM_001257212 NM_033136 NM_033137 NM_001354955 NM_001354956 NM_001354957 NM_001354958 NM_001354959 NM_001354961 NM_001354963 NM_001354964 NM_001354951 NM_001354952 NM_001354953 NM_001354954 NM_001354962	n/a
RefSeq (protein)	NP_000791 NP_001138364 NP_001138406 NP_001138407 NP_001244134 NP_001244135 NP_001244136 NP_001244137 NP_001244138 NP_001244139 NP_001244140 NP_001244141 NP_149127 NP_149128 NP_001341884 NP_001341885 NP_001341886 NP_001341887 NP_001341888 NP_001341890 NP_001341892 NP_001341893 NP_001341880 NP_001341881 NP_001341882 NP_001341883 NP_001341891	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn FGF1 yw FGF1 a elwir hefyd yn Fibroblast growth factor 1 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 5, band 5q31.3.

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn FGF1.

• AFGF
• ECGF
• FGFA
• ECGFA
• ECGFB
• FGF-1
• HBGF1
• HBGF-1
• GLIO703
• ECGF-beta
• FGF-alpha

Llyfryddiaeth

• "Fibroblast Growth Factor 1-Transfected Adipose-Derived Mesenchymal Stem Cells Promote Angiogenic Proliferation. ". DNA Cell Biol. 2017. PMID 28281780.
• "Engineering a Cysteine-Free Form of Human Fibroblast Growth Factor-1 for "Second Generation" Therapeutic Application. ". J Pharm Sci. 2016. PMID 27019961.
• "Identification of new FGF1 binding partners-Implications for its intracellular function. ". IUBMB Life. 2016. PMID 26840910.
• "Folding of Fibroblast Growth Factor 1 Is Critical for Its Nonclassical Release. ". Biochemistry. 2016. PMID 26836284.
• "Fibroblast growth factor 1 levels are elevated in newly diagnosed type 2 diabetes compared to normal glucose tolerance controls.". Endocr J. 2016. PMID 26806193.