FEN1

FEN1
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 1U7B, 1UL1, 3Q8K, 3Q8L, 3Q8M, 3UVU, 5E0V
Dynodwyr
Cyfenwau	FEN1, Flap endonuclease 1, flap structure-specific endonuclease 1, FEN-1, MF1, RAD2
Dynodwyr allanol	OMIM: 600393 HomoloGene: 3034 GeneCards: FEN1
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • metal ion binding • RNA-DNA hybrid ribonuclease activity • hydrolase activity, acting on ester bonds • nuclease activity • hydrolase activity • double-stranded DNA binding • catalytic activity • damaged DNA binding • double-stranded DNA exodeoxyribonuclease activity • GO:0001948, GO:0016582 protein binding • DNA binding • endonuclease activity • exonuclease activity • 5'-3' exonuclease activity • 5'-flap endonuclease activity • flap endonuclease activity • magnesium ion binding • manganese ion binding Cydrannau o'r gell • mitocondria • cnewyllyn cell • bilen • nucleoplasm • nucleolus • GO:0009327 protein-containing complex Prosesau biolegol • double-strand break repair via homologous recombination • double-strand break repair • Cof • cellular response to DNA damage stimulus • UV protection • DNA replication • GO:0100026 DNA repair • RNA phosphodiester bond hydrolysis, endonucleolytic • DNA replication, removal of RNA primer • positive regulation of sister chromatid cohesion • nucleic acid phosphodiester bond hydrolysis • telomere maintenance via semi-conservative replication • base-excision repair • apoptotic DNA fragmentation • retina development in camera-type eye Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	2237	n/a
Ensembl	ENSG00000168496	n/a
UniProt	P39748	n/a
RefSeq (mRNA)	NM_004111	n/a
RefSeq (protein)	NP_004102	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn FEN1 yw FEN1 a elwir hefyd yn Flap structure-specific endonuclease 1 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 11, band 11q12.2.

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn FEN1.

• MF1
• RAD2
• FEN-1

Llyfryddiaeth

• "The FEN1 L209P mutation interferes with long-patch base excision repair and induces cellular transformation. ". Oncogene. 2017. PMID 27270424.
• "DNA and Protein Requirements for Substrate Conformational Changes Necessary for Human Flap Endonuclease-1-catalyzed Reaction. ". J Biol Chem. 2016. PMID 26884332.
• "Flap endonuclease 1 silencing is associated with increasing the cisplatin sensitivity of SGC‑7901 gastric cancer cells. ". Mol Med Rep. 2016. PMID 26718738.
• "The Association of Flap Endonuclease 1 Genotypes with the Risk of Childhood Leukemia. ". Cancer Genomics Proteomics. 2016. PMID 26708601.
• "Variants and haplotypes in Flap endonuclease 1 and risk of gallbladder cancer and gallstones: a population-based study in China.". Sci Rep. 2015. PMID 26668074.