FCGRT

FCGRT
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 1EXU, 3M17, 3M1B, 4K71, 4N0F, 4N0U, 5BXF
Dynodwyr
Cyfenwau	FCGRT, FCRN, alpha-chain, Fc fragment of IgG receptor and transporter, FcgammaRn, Fc gamma receptor and transporter
Dynodwyr allanol	OMIM: 601437 HomoloGene: 3030 GeneCards: FCGRT
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • peptide antigen binding • IgG receptor activity • beta-2-microglobulin binding • IgG binding Cydrannau o'r gell • integral component of membrane • Cellbilen • bilen • extracellular space • external side of plasma membrane Prosesau biolegol • IgG immunoglobulin transcytosis in epithelial cells mediated by FcRn immunoglobulin receptor • Fc-gamma receptor signaling pathway • GO:0046730, GO:0046737, GO:0046738, GO:0046736 immune response Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	2217	n/a
Ensembl	ENSG00000104870	n/a
UniProt	P55899	n/a
RefSeq (mRNA)	NM_001136019 NM_004107	n/a
RefSeq (protein)	NP_001129491 NP_004098	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn FCGRT yw FCGRT a elwir hefyd yn IgG receptor FcRn large subunit p51 a Fc fragment of IgG receptor and transporter (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 19, band 19q13.33.

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn FCGRT.

• FCRN
• alpha-chain

Llyfryddiaeth

• "Associations between an IgG3 polymorphism in the binding domain for FcRn, transplacental transfer of malaria-specific IgG3, and protection against Plasmodium falciparum malaria during infancy: A birth cohort study in Benin. ". PLoS Med. 2017. PMID 28991911.
• "The Neonatal Fc Receptor and Complement Fixation Facilitate Prophylactic Vaccine-Mediated Humoral Protection against Viral Infection in the Ocular Mucosa. ". J Immunol. 2017. PMID 28760885.
• "Correlation of FCGRT genomic structure with serum immunoglobulin, albumin and farletuzumab pharmacokinetics in patients with first relapsed ovarian cancer. ". Genomics. 2017. PMID 28450240.
• "The expression and function of the neonatal Fc receptor in thyrocytes of Hashimoto's thyroiditis. ". Int Immunopharmacol. 2017. PMID 28081504.
• "Neonatal Fc receptor FcRn is involved in intracellular transport of the Fc fusion protein aflibercept and its transition through retinal endothelial cells.". Exp Eye Res. 2017. PMID 27836572.