FCAR

FCAR
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 1OVZ, 1OW0, 1UCT
Dynodwyr
Cyfenwau	FCAR, CD89, CTB-61M7.2, FcalphaRI, Fc fragment of IgA receptor, Fc alpha receptor, FcalphaR
Dynodwyr allanol	OMIM: 147045 HomoloGene: 48064 GeneCards: FCAR
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • IgA receptor activity • IgA binding Cydrannau o'r gell • integral component of membrane • extracellular region • Cellbilen • integral component of plasma membrane • bilen • specific granule membrane • tertiary granule membrane • ficolin-1-rich granule membrane Prosesau biolegol • GO:0046730, GO:0046737, GO:0046738, GO:0046736 immune response • neutrophil degranulation • neutrophil mediated immunity • positive regulation of neutrophil apoptotic process • cellular response to interferon-alpha • Fc receptor signaling pathway • neutrophil activation • cellular response to lipopolysaccharide • cellular response to interferon-gamma • cellular response to interleukin-6 • cellular response to tumor necrosis factor • cellular response to granulocyte macrophage colony-stimulating factor stimulus • positive regulation of oxidative stress-induced cell death Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	2204	n/a
Ensembl	ENSG00000275564 ENSG00000284004 ENSG00000273738 ENSG00000283953 ENSG00000276985 ENSG00000275970 ENSG00000284061 ENSG00000283750 ENSG00000278415 ENSG00000186431 ENSG00000275136 ENSG00000276858 ENSG00000284245 ENSG00000275269 ENSG00000274580	n/a
UniProt	P24071	n/a
RefSeq (mRNA)	NM_002000 NM_133269 NM_133271 NM_133272 NM_133273 NM_133274 NM_133277 NM_133278 NM_133279 NM_133280	n/a
RefSeq (protein)	NP_001991 NP_579803 NP_579805 NP_579806 NP_579807 NP_579808 NP_579811 NP_579812	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn FCAR yw FCAR a elwir hefyd yn Fc fragment of IgA receptor (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 19, band 19q13.42.

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn FCAR.

• CD89
• FcalphaRI
• CTB-61M7.2

Llyfryddiaeth

• "Discovery of a novel splice variant of Fcar (CD89) unravels sequence segments necessary for efficient secretion: A story of bad signal peptides and good ones that nevertheless do not make it. ". Cell Cycle. 2017. PMID 28103138.
• "Targeted IgA Fc receptor I (FcαRI) therapy in the early intervention and treatment of pristane-induced lupus nephritis in mice. ". Clin Exp Immunol. 2015. PMID 25907714.
• "Both IgA nephropathy and alcoholic cirrhosis feature abnormally glycosylated IgA1 and soluble CD89-IgA and IgG-IgA complexes: common mechanisms for distinct diseases. ". Kidney Int. 2011. PMID 21866091.
• "Single nucleotidic polymorphism 844 A->G of FCAR is not associated with IgA nephropathy in Caucasians. ". Nephrol Dial Transplant. 2012. PMID 21750160.
• "Targeting FcαRI on polymorphonuclear cells induces tumor cell killing through autophagy.". J Immunol. 2011. PMID 21653835.