F2R

F2R
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 1NRN, 1NRO, 1NRP, 1NRQ, 1NRR, 3BEF, 3HKI, 3HKJ, 3LU9, 3VW7
Dynodwyr
Cyfenwau	F2R, CHTR, PAR-1, PAR1, TR, Coagulation factor II receptor, coagulation factor II thrombin receptor
Dynodwyr allanol	OMIM: 187930 HomoloGene: 1510 GeneCards: F2R
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • G protein-coupled receptor activity • signal transducer activity • thrombin-activated receptor activity • G-protein beta-subunit binding • GO:0001948, GO:0016582 protein binding • G-protein alpha-subunit binding • signaling receptor binding Cydrannau o'r gell • integral component of membrane • platelet dense tubular network • late endosome • Golgi apparatus • postsynaptic membrane • bilen • neuromuscular junction • Cellbilen • integral component of plasma membrane • extracellular region • cell surface • early endosome • caveola Prosesau biolegol • GO:1904089 negative regulation of neuron apoptotic process • positive regulation of collagen biosynthetic process • hemostasis • establishment of synaptic specificity at neuromuscular junction • release of sequestered calcium ion into cytosol • platelet dense granule organization • regulation of sensory perception of pain • thrombin-activated receptor signaling pathway • positive regulation of cell migration • positive regulation of cytosolic calcium ion concentration • anatomical structure morphogenesis • blood coagulation • positive regulation of release of sequestered calcium ion into cytosol • platelet activation • phospholipase C-activating G protein-coupled receptor signaling pathway • positive regulation of cysteine-type endopeptidase activity involved in apoptotic process • response to lipopolysaccharide • GO:0060469, GO:0009371 positive regulation of transcription, DNA-templated • protein kinase C-activating G protein-coupled receptor signaling pathway • positive regulation of blood coagulation • response to wounding • positive regulation of vasoconstriction • positive regulation of cell population proliferation • connective tissue replacement involved in inflammatory response wound healing • positive regulation of ERK1 and ERK2 cascade • regulation of interleukin-1 beta production • positive regulation of I-kappaB kinase/NF-kappaB signaling • homeostasis of number of cells within a tissue • positive regulation of phosphatidylinositol 3-kinase signaling • regulation of blood coagulation • inflammatory response • negative regulation of glomerular filtration • activation of cysteine-type endopeptidase activity involved in apoptotic process • positive regulation of smooth muscle contraction • positive regulation of MAPK cascade • negative regulation of cell population proliferation • negative regulation of renin secretion into blood stream • GO:0072468 signal transduction • positive regulation of calcium ion transport • positive regulation of Rho protein signal transduction • positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway • trans-synaptic signaling by endocannabinoid, modulating synaptic transmission • GO:0032320, GO:0032321, GO:0032855, GO:0043089, GO:0032854 positive regulation of GTPase activity • cell-cell junction maintenance • G protein-coupled receptor signaling pathway • positive regulation of receptor signaling pathway via JAK-STAT Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	2149	n/a
Ensembl	ENSG00000181104	n/a
UniProt	P25116	n/a
RefSeq (mRNA)	NM_001992 NM_001311313	n/a
RefSeq (protein)	NP_001298242 NP_001983	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn F2R yw F2R a elwir hefyd yn Coagulation factor II thrombin receptor (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 5, band 5q13.3.

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn F2R.

• TR
• HTR
• CF2R
• PAR1
• PAR-1

Llyfryddiaeth

• "Clinical significance of serum protease activated receptor1 levels in patients with lung cancer. ". Eur Rev Med Pharmacol Sci. 2016. PMID 26875892.
• "Cell-Penetrating Pepducin Therapy Targeting PAR1 in Subjects With Coronary Artery Disease. ". Arterioscler Thromb Vasc Biol. 2016. PMID 26681756.
• "PAR1 inhibition suppresses the self-renewal and growth of A2B5-defined glioma progenitor cells and their derived gliomas in vivo. ". Oncogene. 2016. PMID 26616854.
• "Evaluation of the F2R IVS-14A/T PAR1 polymorphism with subsequent cardiovascular events and bleeding in patients who have undergone percutaneous coronary intervention. ". J Thromb Thrombolysis. 2016. PMID 26446588.
• "Down-regulation of PAR1 activity with a pHLIP-based allosteric antagonist induces cancer cell death.". Biochem J. 2015. PMID 26424552.