F2

F2
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 1A2C, 1A3B, 1A3E, 1ABI, 1ABJ, 1AD8, 1AE8, 1AI8, 1AIX, 1AWF, 1AWH, 1AY6, 1B5G, 1B7X, 1BA8, 1BB0, 1BCU, 1BHX, 1BMM, 1BMN, 1BTH, 1C1U, 1C1V, 1C1W, 1C4U, 1C4V, 1C4Y, 1C5L, 1C5N, 1C5O, 1CA8, 1D3D, 1D3P, 1D3Q, 1D3T, 1D4P, 1D6W, 1D9I, 1DE7, 1DIT, 1DM4, 1DOJ, 1DWB, 1DWC, 1DWD, 1DX5, 1E0F, 1EB1, 1EOJ, 1EOL, 1FPC, 1G30, 1G32, 1G37, 1GHV, 1GHW, 1GHX, 1GHY, 1GJ4, 1GJ5, 1H8D, 1H8I, 1HAI, 1HAO, 1HAP, 1HBT, 1HLT, 1HUT, 1HXE, 1HXF, 1IHS, 1JMO, 1JOU, 1JWT, 1K21, 1K22, 1KTS, 1KTT, 1LHC, 1LHD, 1LHE, 1LHF, 1LHG, 1MH0, 1MU6, 1MU8, 1MUE, 1NM6, 1NRN, 1NRO, 1NRP, 1NRQ, 1NRR, 1NRS, 1NT1, 1NU7, 1NU9, 1NY2, 1NZQ, 1O0D, 1O2G, 1O5G, 1OOK, 1OYT, 1P8V, 1PPB, 1QBV, 1QHR, 1QJ1, 1QJ6, 1QJ7, 1QUR, 1RD3, 1RIW, 1SB1, 1SFQ, 1SG8, 1SGI, 1SHH, 1SL3, 1SR5, 1T4U, 1T4V, 1TA2, 1TA6, 1TB6, 1THP, 1THR, 1THS, 1TMB, 1TMU, 1TOM, 1TQ0, 1TQ7, 1TWX, 1UVS, 1VR1, 1VZQ, 1W7G, 1WAY, 1WBG, 1XM1, 1XMN, 1YPE, 1YPG, 1YPJ, 1YPK, 1YPL, 1YPM, 1Z71, 1Z8I, 1Z8J, 1ZGI, 1ZGV, 1ZRB, 2A0Q, 2A2X, 2A45, 2AFQ, 2ANK, 2ANM, 2B5T, 2BDY, 2BVR, 2BVS, 2BVX, 2BXT, 2BXU, 2C8Y, 2FEQ, 2FES, 2GDE, 2GP9, 2H9T, 2HGT, 2HNT, 2HPP, 2HPQ, 2HWL, 2JH0, 2JH6, 2OD3, 2PGB, 2PGQ, 2PW8, 2R2M, 2THF, 2ZFQ, 2ZFR, 2ZG0, 2ZHE, 2ZHF, 2ZHW, 2ZI2, 2ZIQ, 2ZNK, 2ZO3, 3B23, 3B9F, 3BEF, 3BEI, 3BF6, 3BIU, 3BIV, 3BV9, 3C1K, 3C27, 3D49, 3DA9, 3DD2, 3DT0, 3DUX, 3E6P, 3EE0, 3EQ0, 3F68, 3GIC, 3GIS, 3HAT, 3HKJ, 3HTC, 3JZ2, 3LDX, 3LU9, 3NXP, 3P17, 3P6Z, 3P70, 3PO1, 3QGN, 3QLP, 3QTO, 3QTV, 3QWC, 3QX5, 3R3G, 3RLW, 3RLY, 3RM0, 3RM2, 3RML, 3RMM, 3RMN, 3RMO, 3S7H, 3S7K, 3SHA, 3SHC, 3SI3, 3SI4, 3SQE, 3SQH, 3SV2, 3T5F, 3TU7, 3U69, 3U8O, 3U8R, 3U8T, 3U98, 3U9A, 3UTU, 3UWJ, 3VXE, 3VXF, 4BAH, 4BAK, 4BAM, 4BAN, 4BAO, 4BAQ, 4BOH, 4DIH, 4DII, 4DT7, 4DY7, 4E05, 4E06, 4E7R, 4H6S, 4H6T, 4HFP, 4HTC, 4THN, 5GDS, 7KME, 8KME, 1A46, 1A4W, 1A5G, 1A61, 1AFE, 1AHT, 1DWE, 1FPH, 1HAG, 1HAH, 1HDT, 1HGT, 1IHT, 1NO9, 1TBZ, 1TMT, 1UMA, 2C8W, 2C8X, 2C8Z, 2C90, 2C93, 2CF8, 2CF9, 2CN0, 2JH5, 2PKS, 2UUF, 2UUJ, 2UUK, 2V3H, 2V3O, 2ZC9, 2ZDA, 2ZDV, 2ZF0, 2ZFF, 2ZFP, 2ZGB, 2ZGX, 2ZHQ, 3DHK, 3EGK, 3JZ1, 3K65, 3PMH, 3QDZ, 4AX9, 4AYV, 4AYY, 4AZ2, 4CH2, 4CH8, 4HZH, 4I7Y, 4LOY, 4LXB, 4LZ1, 4LZ4, 4MLF, 4N3L, 4NZE, 4NZQ, 4O03, 4RKJ, 4RKO, 4RN6, 4YES, 4UD9, 4UDW, 4UE7, 4UEH, 5AF9, 5AFY, 5AFZ, 5AHG, 5CMX, 4UFD, 5EDM, 5E8E, 5EDK, 4UFE, 4UFG, 4UFF, 5A2M, 5JDU
Dynodwyr
Cyfenwau	F2, PT, RPRGL2, THPH1, coagulation factor II, thrombin
Dynodwyr allanol	OMIM: 176930 HomoloGene: 426 GeneCards: F2
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • calcium ion binding • signaling receptor binding • GO:0070122 peptidase activity • hydrolase activity • growth factor activity • serine-type peptidase activity • thrombospondin receptor activity • GO:0001948, GO:0016582 protein binding • serine-type endopeptidase activity • lipopolysaccharide binding • heparin binding • GO:0010577 enzyme activator activity Cydrannau o'r gell • extracellular exosome • blood microparticle • endoplasmic reticulum lumen • Golgi lumen • Cellbilen • extracellular region • extracellular space • external side of plasma membrane • collagen-containing extracellular matrix Prosesau biolegol • blood coagulation, intrinsic pathway • regulation of blood coagulation • positive regulation of phosphatidylinositol 3-kinase signaling • positive regulation of collagen biosynthetic process • multicellular organism development • peptidyl-glutamic acid carboxylation • acute-phase response • positive regulation of reactive oxygen species metabolic process • endoplasmic reticulum to Golgi vesicle-mediated transport • positive regulation of cell growth • cell surface receptor signaling pathway • regulation of gene expression • positive regulation of release of sequestered calcium ion into cytosol • positive regulation of cell population proliferation • leukocyte migration • negative regulation of fibrinolysis • positive regulation of blood coagulation • regulation of cytosolic calcium ion concentration • response to wounding • signal peptide processing • positive regulation of phospholipase C-activating G protein-coupled receptor signaling pathway • regulation of cell shape • hemostasis • negative regulation of proteolysis • negative regulation of platelet activation • negative regulation of astrocyte differentiation • positive regulation of protein phosphorylation • fibrinolysis • blood coagulation • proteolysis • platelet activation • positive regulation of protein localization to nucleus • positive regulation of lipid kinase activity • regulation of complement activation • antimicrobial humoral immune response mediated by antimicrobial peptide • negative regulation of cytokine production involved in inflammatory response • regulation of signaling receptor activity • G protein-coupled receptor signaling pathway • positive regulation of receptor signaling pathway via JAK-STAT • blood coagulation, fibrin clot formation Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	2147	n/a
Ensembl	ENSG00000180210	n/a
UniProt	P00734	n/a
RefSeq (mRNA)	NM_000506 NM_001311257	n/a
RefSeq (protein)	NP_000497	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn F2 yw F2 a elwir hefyd yn Coagulation factor II, thrombin (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 11, band 11p11.2.

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn F2.

• PT
• THPH1
• RPRGL2

Llyfryddiaeth

• "Clinical significance of prothrombin G20210A mutation in homozygous patients. ". Am J Hematol. 2017. PMID 28707429.
• "Non-canonical proteolytic activation of human prothrombin by subtilisin from Bacillus subtilismay shift the procoagulant-anticoagulant equilibrium toward thrombosis. ". J Biol Chem. 2017. PMID 28684417.
• "Phenotypic and genetic analysis of dysprothrombinemia due to a novel homozygous mutation. ". Hematology. 2017. PMID 28196451.
• "Association Between the 20210G>A Prothrombin Gene Polymorphism and Arterial Ischemic Stroke in Children and Young Adults-Two Meta-analyses of 3586 Cases and 6440 Control Subjects in Total. ". Pediatr Neurol. 2017. PMID 28160964.
• "Prothrombin Loading of Vascular Smooth Muscle Cell-Derived Exosomes Regulates Coagulation and Calcification.". Arterioscler Thromb Vasc Biol. 2017. PMID 28104608.