EYA2

EYA2
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 3GEB, 3HB0, 3HB1, 4EGC
Dynodwyr
Cyfenwau	EYA2, EAB1, EYA transcriptional coactivator and phosphatase 2
Dynodwyr allanol	OMIM: 601654 HomoloGene: 40711 GeneCards: EYA2
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • phosphoprotein phosphatase activity • metal ion binding • GO:0001948, GO:0016582 protein binding • protein tyrosine phosphatase activity • hydrolase activity • magnesium ion binding • transcription factor binding Cydrannau o'r gell • cytoplasm • nucleoplasm • mitocondria • cnewyllyn cell • cytosol Prosesau biolegol • striated muscle tissue development • GO:0009373 regulation of transcription, DNA-templated • GO:0016576 protein dephosphorylation • transcription, DNA-templated • cellular response to DNA damage stimulus • multicellular organism development • extrinsic apoptotic signaling pathway in absence of ligand • mesodermal cell fate specification • mitochondrial outer membrane permeabilization • GO:1900404 positive regulation of DNA repair • peptidyl-tyrosine dephosphorylation • GO:0100026 DNA repair • negative regulation of extrinsic apoptotic signaling pathway in absence of ligand • GO:0031497, GO:0006336, GO:0034724, GO:0001301, GO:0007580, GO:0034652, GO:0010847 chromatin organization • GO:1903374 anatomical structure development Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	2139	n/a
Ensembl	ENSG00000064655	n/a
UniProt	O00167	n/a
RefSeq (mRNA)	NM_005244 NM_172110 NM_172111 NM_172112 NM_172113	n/a
RefSeq (protein)	NP_005235 NP_742108	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn EYA2 yw EYA2 a elwir hefyd yn EYA transcriptional coactivator and phosphatase 2 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 20, band 20q13.12.

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn EYA2.

• EAB1

Llyfryddiaeth

• "Aberrant hypomethylation and overexpression of the eyes absent homologue 2 suppresses tumor cell growth of human lung adenocarcinoma cells. ". Oncol Rep. 2015. PMID 26329363.
• "Epigenetic silencing of EYA2 in pancreatic adenocarcinomas promotes tumor growth. ". Oncotarget. 2014. PMID 24810906.
• "Human HAD phosphatases: structure, mechanism, and roles in health and disease. ". FEBS J. 2013. PMID 22607316.
• "[Expression of EYA2 in non-small cell lang cancer]. ". Zhonghua Zhong Liu Za Zhi. 2009. PMID 19950702.
• "Crystal structure of ED-Eya2: insight into dual roles as a protein tyrosine phosphatase and a transcription factor.". FASEB J. 2010. PMID 19858093.