EXOSC8

EXOSC8
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 2NN6
Dynodwyr
Cyfenwau	EXOSC8, CIP3, EAP2, OIP2, RRP43, Rrp43p, bA421P11.3, p9, PCH1C, Exosome component 8
Dynodwyr allanol	OMIM: 606019 HomoloGene: 12323 GeneCards: EXOSC8
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • exoribonuclease activity • GO:0001948, GO:0016582 protein binding • RNA binding • identical protein binding • mRNA 3'-UTR AU-rich region binding Cydrannau o'r gell • cytoplasm • cytosol • exosome (RNase complex) • nucleolus • cnewyllyn cell • nucleoplasm • nuclear exosome (RNase complex) • cytoplasmic exosome (RNase complex) Prosesau biolegol • regulation of mRNA stability • GO:0033168, GO:0036404, GO:1902360 RNA processing • RNA catabolic process • rRNA processing • exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) • nuclear-transcribed mRNA catabolic process, exonucleolytic, 3'-5' • U1 snRNA 3'-end processing • U4 snRNA 3'-end processing • U5 snRNA 3'-end processing • exonucleolytic catabolism of deadenylated mRNA • GO:0071049, GO:0071048, GO:0071033 nuclear mRNA surveillance • nuclear polyadenylation-dependent rRNA catabolic process • nuclear polyadenylation-dependent tRNA catabolic process • nuclear polyadenylation-dependent mRNA catabolic process • GO:0022610 proses fiolegol • rRNA catabolic process Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	11340	n/a
Ensembl	ENSG00000120699	n/a
UniProt	Q96B26	n/a
RefSeq (mRNA)	NM_181503	n/a
RefSeq (protein)	NP_852480	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn EXOSC8 yw EXOSC8 a elwir hefyd yn Exosome component 8 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 13, band 13q13.3.

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn EXOSC8.

• p9
• CIP3
• EAP2
• OIP2
• PCH1C
• RRP43
• Rrp43p
• bA421P11.3

Llyfryddiaeth

• "Characterization of the VHL tumor suppressor gene product: localization, complex formation, and the effect of natural inactivating mutations. ". Proc Natl Acad Sci U S A. 1995. PMID 7604013.
• "Protein-protein interactions with subunits of human nuclear RNase P. ". Proc Natl Acad Sci U S A. 2001. PMID 11158571.
• "A protein subunit of human RNase P, Rpp14, and its interacting partner, OIP2, have 3'-->5' exoribonuclease activity. ". Proc Natl Acad Sci U S A. 2002. PMID 11929972.
• "Exosome-bound WD repeat protein Monad inhibits breast cancer cell invasion by degrading amphiregulin mRNA. ". PLoS One. 2013. PMID 23844004.
• "Sequence-specific RNA binding mediated by the RNase PH domain of components of the exosome.". RNA. 2006. PMID 16912217.