EXOSC2

EXOSC2
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 2NN6
Dynodwyr
Cyfenwau	EXOSC2, RRP4, Rrp4p, hRrp4p, p7, Exosome component 2, SHRF
Dynodwyr allanol	OMIM: 602238 HomoloGene: 6095 GeneCards: EXOSC2
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • 3'-5'-exoribonuclease activity • exoribonuclease activity • 7S RNA binding • GO:0001948, GO:0016582 protein binding • RNA binding Cydrannau o'r gell • cytoplasm • cytosol • exosome (RNase complex) • nuclear exosome (RNase complex) • cytoplasmic exosome (RNase complex) • cnewyllyn cell • nucleoplasm • nucleolus Prosesau biolegol • nuclear polyadenylation-dependent tRNA catabolic process • nuclear polyadenylation-dependent rRNA catabolic process • regulation of mRNA stability • exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) • nuclear-transcribed mRNA catabolic process, exonucleolytic, 3'-5' • CUT catabolic process • positive regulation of cell growth • exonucleolytic catabolism of deadenylated mRNA • rRNA processing • U4 snRNA 3'-end processing • polyadenylation-dependent snoRNA 3'-end processing Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	23404	n/a
Ensembl	ENSG00000130713	n/a
UniProt	Q13868	n/a
RefSeq (mRNA)	NM_001282708 NM_001282709 NM_014285	n/a
RefSeq (protein)	NP_001269637 NP_001269638 NP_055100	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn EXOSC2 yw EXOSC2 a elwir hefyd yn Exosome component 2 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 9, band 9q34.12.

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn EXOSC2.

• p7
• RRP4
• SHRF
• Rrp4p
• hRrp4p

Llyfryddiaeth

• "The first intron in the human c-abl gene is at least 200 kilobases long and is a target for translocations in chronic myelogenous leukemia. ". Mol Cell Biol. 1987. PMID 3313010.
• "Alternative splicing of RNAs transcribed from the human abl gene and from the bcr-abl fused gene. ". Cell. 1986. PMID 3021337.
• "Mutations in EXOSC2 are associated with a novel syndrome characterised by retinitis pigmentosa, progressive hearing loss, premature ageing, short stature, mild intellectual disability and distinctive gestalt. ". J Med Genet. 2016. PMID 26843489.
• "The 3' end of yeast 5.8S rRNA is generated by an exonuclease processing mechanism. ". Genes Dev. 1996. PMID 8600032.
• "The human v-abl cellular homologue.". J Mol Appl Genet. 1983. PMID 6302194.