EXOSC10

EXOSC10
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 2CPR, 3SAF, 3SAG, 3SAH
Dynodwyr
Cyfenwau	EXOSC10, PM-Scl, PM/Scl-100, PMSCL, PMSCL2, RRP6, Rrp6p, p2, p3, p4, exosome component 10
Dynodwyr allanol	OMIM: 605960 HomoloGene: 31105 GeneCards: EXOSC10
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • nucleotide binding • exoribonuclease activity • GO:0001948, GO:0016582 protein binding • catalytic activity • 3'-5' exonuclease activity • nucleic acid binding • nuclease activity • exonuclease activity • hydrolase activity • RNA binding • 3'-5'-exoribonuclease activity • telomerase RNA binding • single-stranded RNA binding Cydrannau o'r gell • cytoplasm • exosome (RNase complex) • bilen • nuclear exosome (RNase complex) • intracellular anatomical structure • nucleolus • cnewyllyn cell • nucleoplasm • cytosol Prosesau biolegol • GO:0033168, GO:0036404, GO:1902360 RNA processing • nuclear polyadenylation-dependent rRNA catabolic process • nucleic acid phosphodiester bond hydrolysis • CUT catabolic process • nuclear-transcribed mRNA catabolic process • GO:0071049, GO:0071048, GO:0071033 nuclear mRNA surveillance • metaboledd celloedd • maturation of 5.8S rRNA • histone mRNA catabolic process • dosage compensation by inactivation of X chromosome • nucleobase-containing compound metabolic process • rRNA processing • RNA phosphodiester bond hydrolysis, exonucleolytic • nuclear-transcribed mRNA catabolic process, nonsense-mediated decay • negative regulation of telomere maintenance via telomerase • regulation of telomerase RNA localization to Cajal body • exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) • nuclear polyadenylation-dependent snoRNA catabolic process • nuclear polyadenylation-dependent snRNA catabolic process • nuclear polyadenylation-dependent tRNA catabolic process • nuclear polyadenylation-dependent CUT catabolic process • nuclear polyadenylation-dependent antisense transcript catabolic process • polyadenylation-dependent snoRNA 3'-end processing Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	5394	n/a
Ensembl	ENSG00000171824	n/a
UniProt	Q01780	n/a
RefSeq (mRNA)	NM_001001998 NM_002685	n/a
RefSeq (protein)	NP_001001998 NP_002676	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn EXOSC10 yw EXOSC10 a elwir hefyd yn Exosome component 10 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 1, band 1p36.22.

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn EXOSC10.

• p2
• p3
• p4
• RRP6
• PMSCL
• Rrp6p
• PM-Scl
• PMSCL2
• PM/Scl-100

Llyfryddiaeth

• "Antibodies against PM/Scl-75 and PM/Scl-100 are independent markers for different subsets of systemic sclerosis patients. ". Arthritis Res Ther. 2009. PMID 19220911.
• "PM1-Alpha ELISA: the assay of choice for the detection of anti-PM/Scl autoantibodies?". Autoimmun Rev. 2009. PMID 19103309.
• "Cooling-induced SUMOylation of EXOSC10 down-regulates ribosome biogenesis. ". RNA. 2016. PMID 26857222.
• "Anti-PM-Scl antibody in patients with systemic sclerosis. ". Clin Exp Rheumatol. 2012. PMID 22261302.
• "Activities of human RRP6 and structure of the human RRP6 catalytic domain.". RNA. 2011. PMID 21705430.