ETS1

ETS1
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 1GVJ, 2NNY, 2STT, 2STW, 3MFK, 3RI4, 3WTS, 3WTT, 3WTU, 3WTV, 3WTW, 3WTX, 3WTY, 3WTZ, 3WU0, 3WU1, 4L0Y, 4L0Z, 4L18, 4LG0
Dynodwyr
Cyfenwau	ETS1, ETS-1, EWSR2, p54, c-ets-1, ETS proto-oncogene 1, transcription factor
Dynodwyr allanol	OMIM: 164720 HomoloGene: 3837 GeneCards: ETS1
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • DNA binding • sequence-specific DNA binding • GO:0001131, GO:0001151, GO:0001130, GO:0001204 DNA-binding transcription factor activity • transcription factor binding • GO:0001948, GO:0016582 protein binding • identical protein binding • transcription factor activity, RNA polymerase II core promoter proximal region sequence-specific binding • GO:0000980 RNA polymerase II cis-regulatory region sequence-specific DNA binding • GO:0001077, GO:0001212, GO:0001213, GO:0001211, GO:0001205 DNA-binding transcription activator activity, RNA polymerase II-specific • sequence-specific double-stranded DNA binding • GO:0001200, GO:0001133, GO:0001201 DNA-binding transcription factor activity, RNA polymerase II-specific • histone acetyltransferase binding Cydrannau o'r gell • cytoplasm • transcription regulator complex • nucleoplasm • cnewyllyn cell Prosesau biolegol • regulation of apoptotic process • pituitary gland development • response to estradiol • response to interleukin-1 • response to hypoxia • GO:0009373 regulation of transcription, DNA-templated • positive regulation of erythrocyte differentiation • cell motility • estrous cycle • immune system process • GO:0044324, GO:0003256, GO:1901213, GO:0046019, GO:0046020, GO:1900094, GO:0061216, GO:0060994, GO:1902064, GO:0003258, GO:0072212 regulation of transcription by RNA polymerase II • GO:1904576 response to antibiotic • female pregnancy • angiogenesis involved in wound healing • positive regulation of cell migration • response to mechanical stimulus • response to laminar fluid shear stress • negative regulation of cell cycle • regulation of angiogenesis • transcription by RNA polymerase II • regulation of extracellular matrix disassembly • transcription, DNA-templated • positive regulation of endothelial cell migration • GO:0060469, GO:0009371 positive regulation of transcription, DNA-templated • PML body organization • response to wounding • GO:0046730, GO:0046737, GO:0046738, GO:0046736 immune response • positive regulation of cell population proliferation • hypothalamus development • negative regulation of inflammatory response • GO:0003257, GO:0010735, GO:1901228, GO:1900622, GO:1904488 positive regulation of transcription by RNA polymerase II • negative regulation of cell population proliferation • cellular response to hydrogen peroxide • positive regulation of inflammatory response • pri-miRNA transcription by RNA polymerase II • positive regulation of leukocyte adhesion to vascular endothelial cell • GO:1901313 positive regulation of gene expression • positive regulation of blood vessel endothelial cell migration • positive regulation of angiogenesis • cell differentiation Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	2113	n/a
Ensembl	ENSG00000134954	n/a
UniProt	P14921	n/a
RefSeq (mRNA)	NM_001143820 NM_001162422 NM_005238 NM_001330451	n/a
RefSeq (protein)	NP_001137292 NP_001155894 NP_001317380 NP_005229	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn ETS1 yw ETS1 a elwir hefyd yn ETS proto-oncogene 1, transcription factor (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 11, band 11q24.3.

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn ETS1.

• p54
• ETS-1
• EWSR2
• c-ets-1

Llyfryddiaeth

• "Phosphorylation of ETS-1 is a critical event in DNA polymerase iota-induced invasion and metastasis of esophageal squamous cell carcinoma. ". Cancer Sci. 2017. PMID 28905458.
• "The caspase-generated cleavage product of Ets-1 p51 and Ets-1 p27, Cp17, induces apoptosis. ". Biochem Biophys Res Commun. 2016. PMID 27737766.
• "Association of E26 Transformation Specific Sequence 1 Variants with Rheumatoid Arthritis in Chinese Han Population. ". PLoS One. 2015. PMID 26241881.
• "A Role for Autoinhibition in Preventing Dimerization of the Transcription Factor ETS1. ". J Biol Chem. 2015. PMID 26195629.
• "Impact of V-ets Erythroblastosis Virus E26 Oncogene Homolog 1 Gene Polymorphisms Upon Susceptibility to Autoimmune Diseases: A Meta-Analysis.". Medicine (Baltimore). 2015. PMID 26039128.