ESRRA

ESRRA
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 1XB7, 2PJL, 3D24, 3K6P
Dynodwyr
Cyfenwau	ESRRA, ERR1, ERRa, ERRalpha, ESRL1, NR3B1, estrogen related receptor alpha
Dynodwyr allanol	OMIM: 601998 HomoloGene: 136738 GeneCards: ESRRA
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • DNA binding • sequence-specific DNA binding • protein domain specific binding • GO:0001131, GO:0001151, GO:0001130, GO:0001204 DNA-binding transcription factor activity • zinc ion binding • GO:0001077, GO:0001212, GO:0001213, GO:0001211, GO:0001205 DNA-binding transcription activator activity, RNA polymerase II-specific • metal ion binding • GO:0000980 RNA polymerase II cis-regulatory region sequence-specific DNA binding • steroid hormone receptor activity • GO:0001078, GO:0001214, GO:0001206 DNA-binding transcription repressor activity, RNA polymerase II-specific • GO:0038050, GO:0004886, GO:0038051 nuclear receptor activity • steroid binding • GO:0001948, GO:0016582 protein binding • GO:0001200, GO:0001133, GO:0001201 DNA-binding transcription factor activity, RNA polymerase II-specific Cydrannau o'r gell • microtubule cytoskeleton • nucleoplasm • intercellular bridge • cnewyllyn cell • fibrillar center • cytoplasm Prosesau biolegol • response to estradiol • GO:0009373 regulation of transcription, DNA-templated • positive regulation of cellular response to insulin stimulus • mitochondrion organization • GO:1901227 negative regulation of transcription by RNA polymerase II • transcription, DNA-templated • GO:0060469, GO:0009371 positive regulation of transcription, DNA-templated • cartilage development • regulation of cell population proliferation • regulation of osteoblast differentiation • regulation of osteoclast differentiation • regulation of ossification • transcription initiation from RNA polymerase II promoter • GO:0003257, GO:0010735, GO:1901228, GO:1900622, GO:1904488 positive regulation of transcription by RNA polymerase II • steroid hormone mediated signaling pathway • intracellular receptor signaling pathway Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	2101	n/a
Ensembl	ENSG00000173153	n/a
UniProt	P11474	n/a
RefSeq (mRNA)	NM_001282450 NM_001282451 NM_004451	n/a
RefSeq (protein)	NP_001269379 NP_001269380 NP_004442	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn ESRRA yw ESRRA a elwir hefyd yn Estrogen related receptor alpha (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 11, band 11q13.1.

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn ESRRA.

• ERR1
• ERRa
• ESRL1
• NR3B1
• ERRalpha

Llyfryddiaeth

• "miR-135a Inhibits the Invasion of Cancer Cells via Suppression of ERRα. ". PLoS One. 2016. PMID 27227989.
• "ERRα Is a Marker of Tamoxifen Response and Survival in Triple-Negative Breast Cancer. ". Clin Cancer Res. 2016. PMID 26542058.
• "Estrogen related receptor α (ERRα) a promising target for the therapy of adrenocortical carcinoma (ACC). ". Oncotarget. 2015. PMID 26312764.
• "Inhibition of ERRα suppresses epithelial mesenchymal transition of triple negative breast cancer cells by directly targeting fibronectin. ". Oncotarget. 2015. PMID 26160845.
• "Association of estrogen receptor β and estrogen-related receptor α gene polymorphisms with bone mineral density in postmenopausal women.". Mol Cell Biochem. 2015. PMID 25903400.