ERG

ERG
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 1SXE, 4IRG, 4IRH, 4IRI
Dynodwyr
Cyfenwau	ERG, erg-3, p55, ETS-related gene, v-ets avian erythroblastosis virus E26 oncogene homolog, ETS transcription factor, ETS transcription factor ERG
Dynodwyr allanol	OMIM: 165080 HomoloGene: 15848 GeneCards: ERG
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • DNA binding • sequence-specific DNA binding • GO:0001131, GO:0001151, GO:0001130, GO:0001204 DNA-binding transcription factor activity • chromatin binding • signal transducer activity • GO:0001948, GO:0016582 protein binding • GO:0000980 RNA polymerase II cis-regulatory region sequence-specific DNA binding • GO:0001077, GO:0001212, GO:0001213, GO:0001211, GO:0001205 DNA-binding transcription activator activity, RNA polymerase II-specific • GO:0001200, GO:0001133, GO:0001201 DNA-binding transcription factor activity, RNA polymerase II-specific Cydrannau o'r gell • cytoplasm • cnewyllyn cell • ribonucleoprotein complex Prosesau biolegol • cell differentiation • GO:0009373 regulation of transcription, DNA-templated • endocardial cushion development • endocardial cushion to mesenchymal transition involved in heart valve formation • transcription, DNA-templated • multicellular organism development • positive regulation of blood vessel remodeling • protein phosphorylation • cell population proliferation • cell migration • GO:0072468 signal transduction • GO:0003257, GO:0010735, GO:1901228, GO:1900622, GO:1904488 positive regulation of transcription by RNA polymerase II • transcription by RNA polymerase II • GO:0044324, GO:0003256, GO:1901213, GO:0046019, GO:0046020, GO:1900094, GO:0061216, GO:0060994, GO:1902064, GO:0003258, GO:0072212 regulation of transcription by RNA polymerase II Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	2078	n/a
Ensembl	ENSG00000157554	n/a
UniProt	P11308	n/a
RefSeq (mRNA)	NM_001136154 NM_001136155 NM_001243428 NM_001243429 NM_001243432 NM_001243433 NM_001291391 NM_004449 NM_182918 NM_001331025	n/a
RefSeq (protein)	NP_001129626 NP_001129627 NP_001230357 NP_001230358 NP_001230361 NP_001278320 NP_001317954 NP_004440 NP_891548	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn ERG yw ERG a elwir hefyd yn Erythroblast transformation-specific transcription factor ERG variant 10 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 21, band 21q22.2.

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn ERG.

• p55
• erg-3

Llyfryddiaeth

• "Phosphorylation of the oncogenic transcription factor ERG in prostate cells dissociates polycomb repressive complex 2, allowing target gene activation. ". J Biol Chem. 2017. PMID 28887309.
• "Prostate cancer with different ERG status may show different FOXP3-positive cell numbers. ". Pol J Pathol. 2016. PMID 28547958.
• "Noninvasive Prenatal Diagnosis Significance of ERG Methylation as a Biomarker in Down's Syndrome. ". Med Sci Monit. 2017. PMID 28111453.
• "Evaluation of ERG and PTEN protein expression in cribriform architecture prostate carcinomas. ". Pathol Res Pract. 2017. PMID 27913052.
• "Heterogeneity of ERG expression in prostate cancer: a large section mapping study of entire prostatectomy specimens from 125 patients.". BMC Cancer. 2016. PMID 27530104.