ERCC4

ERCC4
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 1Z00, 2A1J, 2MUT, 2KN7, 2AQ0
Dynodwyr
Cyfenwau	ERCC4, ERCC11, FANCQ, RAD1, XPF, XFEPS, excision repair cross-complementation group 4, ERCC excision repair 4, endonuclease catalytic subunit
Dynodwyr allanol	OMIM: 133520 HomoloGene: 3836 GeneCards: ERCC4
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • protein N-terminus binding • damaged DNA binding • protein C-terminus binding • GO:0001948, GO:0016582 protein binding • TFIID-class transcription factor complex binding • nuclease activity • endonuclease activity • hydrolase activity • endodeoxyribonuclease activity • single-stranded DNA binding • telomerase inhibitor activity • 3' overhang single-stranded DNA endodeoxyribonuclease activity • DNA binding • identical protein binding • single-stranded DNA endodeoxyribonuclease activity Cydrannau o'r gell • ERCC4-ERCC1 complex • transcription factor TFIID complex • nucleoplasm • telomere • nucleotide-excision repair factor 1 complex • nucleotide-excision repair complex • cnewyllyn cell Prosesau biolegol • resolution of meiotic recombination intermediates • interstrand cross-link repair • cellular response to UV • cellular response to DNA damage stimulus • global genome nucleotide-excision repair • nucleotide-excision repair involved in interstrand cross-link repair • UV protection • negative regulation of telomere maintenance • transcription-coupled nucleotide-excision repair • nucleotide-excision repair, DNA incision • telomere maintenance • response to UV • double-strand break repair via homologous recombination • GO:0100026 DNA repair • nucleotide-excision repair, DNA incision, 3'-to lesion • nucleotide-excision repair • nucleotide-excision repair, DNA incision, 5'-to lesion • nucleotide-excision repair, preincision complex stabilization • double-strand break repair via nonhomologous end joining • negative regulation of telomerase activity • negative regulation of telomere maintenance via telomere lengthening • negative regulation of protection from non-homologous end joining at telomere • negative regulation of double-stranded telomeric DNA binding • telomeric DNA-containing double minutes formation • regulation of autophagy Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	2072	n/a
Ensembl	ENSG00000175595	n/a
UniProt	Q92889	n/a
RefSeq (mRNA)	NM_005236	n/a
RefSeq (protein)	NP_005227	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn ERCC4 yw ERCC4 a elwir hefyd yn ERCC excision repair 4, endonuclease catalytic subunit (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 16, band 16p13.12.

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn ERCC4.

• XPF
• RAD1
• FANCQ
• XFEPS
• ERCC11

Llyfryddiaeth

• "Higher expression of XPF is a critical factor in intrinsic chemotherapy resistance of human renal cell carcinoma. ". Int J Cancer. 2016. PMID 27542841.
• "Association of XPF Levels and Genetic Polymorphism with Susceptibility to Ischemic Stroke. ". J Mol Neurosci. 2016. PMID 26888738.
• "The Role of the XPF Gene Polymorphism (Xrcc4) Ser835ser in the Risk of Malignant Transformation of Cells in the Colorectal Cancer. ". Pol Przegl Chir. 2015. PMID 26146099.
• "Lack of association between XPF polymorphisms and gastric cancer risk: a meta-analysis. ". Oncol Res Treat. 2014. PMID 25342505.
• "Associations of ERCC4 rs1800067 polymorphism with cancer risk: an updated meta-analysis.". Asian Pac J Cancer Prev. 2014. PMID 25292041.