ERBIN

ERBIN
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 1MFG, 1MFL, 1N7T, 2H3L, 2QBW, 3CH8
Dynodwyr
Cyfenwau	ERBIN, HEL-S-78, LAP2, ERBB2IP, erbb2 interacting protein
Dynodwyr allanol	OMIM: 606944 HomoloGene: 41282 GeneCards: ERBIN
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • structural constituent of cytoskeleton • ErbB-2 class receptor binding • GO:0001948, GO:0016582 protein binding • signaling receptor binding Cydrannau o'r gell • cytoplasm • nuclear membrane • bilen • Cellbilen • hemidesmosome • basement membrane • cell junction • basal plasma membrane • basolateral plasma membrane • cnewyllyn cell • nuclear speck • neuromuscular junction • postsynapse • glutamatergic synapse • postsynaptic specialization Prosesau biolegol • negative regulation of monocyte chemotactic protein-1 production • protein targeting • epidermal growth factor receptor signaling pathway • negative regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway • cellular response to tumor necrosis factor • response to muramyl dipeptide • basal protein localization • cell growth • response to lipopolysaccharide • cell adhesion • establishment or maintenance of epithelial cell apical/basal polarity • intermediate filament cytoskeleton organization • integrin-mediated signaling pathway • negative regulation of NF-kappaB transcription factor activity • GO:0072468 signal transduction • ERBB2 signaling pathway • regulation of postsynaptic membrane neurotransmitter receptor levels Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	55914	n/a
Ensembl	ENSG00000112851	n/a
UniProt	Q96RT1	n/a
RefSeq (mRNA)	NM_001006600 NM_001253697 NM_001253698 NM_001253699 NM_001253701 NM_018695	n/a
RefSeq (protein)	NP_001006600 NP_001240626 NP_001240627 NP_001240628 NP_001240630 NP_061165	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn ERBIN yw ERBIN a elwir hefyd yn Erbb2 interacting protein (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 5, band 5q12.3.

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn ERBIN.

• LAP2
• ERBB2IP
• HEL-S-78

Llyfryddiaeth

• "Erbin loss promotes cancer cell proliferation through feedback activation of Akt-Skp2-p27 signaling. ". Biochem Biophys Res Commun. 2015. PMID 26025650.
• "Alteration of the C-terminal ligand specificity of the erbin PDZ domain by allosteric mutational effects. ". J Mol Biol. 2014. PMID 24813123.
• "LAP2 is widely overexpressed in diverse digestive tract cancers and regulates motility of cancer cells. ". PLoS One. 2012. PMID 22745766.
• "Densin-180: revised membrane topology, domain structure and phosphorylation status. ". J Neurochem. 2009. PMID 19187442.
• "Palmitoylation of ERBIN is required for its plasma membrane localization.". Genes Cells. 2008. PMID 18498353.