ERBB4

ERBB4
Strwythurau
PDB	Human UniProt search: PDBe RCSB
Rhestr o ddynodwyr PDB
	2AHX, 2L2T, 2LCX, 2R4B, 3BBT, 3BBW, 3BCE, 3U2P, 3U7U, 3U9U
Dynodwyr
Cyfenwau	ERBB4, ALS19, HER4, p180erbB4, erb-b2 receptor tyrosine kinase 4
Dynodwyr allanol	OMIM: 600543 HomoloGene: 21084 GeneCards: ERBB4
Patrwm RNA pattern
	Rhagor o gyfeiriadau
Ontoleg y genyn
Gweithrediad moleciwlaidd	• transferase activity; • nucleotide binding; • protein kinase activity; • protein homodimerization activity; • epidermal growth factor receptor binding; • kinase activity; • GO:0001948, GO:0016582 protein binding; • transmembrane receptor protein tyrosine kinase activity; • ATP binding; • protein tyrosine kinase activity; • phosphatidylinositol-4,5-bisphosphate 3-kinase activity; • receptor tyrosine kinase; • transmembrane signaling receptor activity;
Cydrannau o'r gell	• integral component of membrane; • cytosol; • bilen; • receptor complex; • Cellbilen; • nucleoplasm; • extracellular region; • mitochondrial matrix; • basolateral plasma membrane; • mitocondria; • cnewyllyn cell; • postsynaptic membrane; • glutamatergic synapse; • GABA-ergic synapse; • integral component of presynaptic membrane; • integral component of postsynaptic density membrane; • cytoplasm; • integral component of plasma membrane; • basal plasma membrane;
Prosesau biolegol	• mitochondrial fragmentation involved in apoptotic process; • negative regulation of neuron migration; • cell fate commitment; • positive regulation of protein phosphorylation; • regulation of cell migration; • GO:0009373 regulation of transcription, DNA-templated; • olfactory bulb interneuron differentiation; • embryonic pattern specification; • phosphorylation; • transmembrane receptor protein tyrosine kinase signaling pathway; • central nervous system morphogenesis; • mammary gland alveolus development; • transcription, DNA-templated; • nervous system development; • mammary gland epithelial cell differentiation; • MAPK cascade; • positive regulation of phosphatidylinositol 3-kinase activity; • GO:0060469, GO:0009371 positive regulation of transcription, DNA-templated; • multicellular organism development; • heart development; • protein phosphorylation; • positive regulation of cardiac muscle cell proliferation; • neural crest cell migration; • positive regulation of ERK1 and ERK2 cascade; • positive regulation of protein localization to cell surface; • protein autophosphorylation; • cardiac muscle tissue regeneration; • positive regulation of phosphatidylinositol 3-kinase signaling; • peptidyl-tyrosine phosphorylation; • lactation; • cell population proliferation; • cell migration; • GO:0072468 signal transduction; • negative regulation of cell population proliferation; • GO:0097285 apoptotic process; • ERBB2 signaling pathway; • phosphatidylinositol phosphate biosynthetic process; • peptidyl-tyrosine autophosphorylation; • positive regulation of cell population proliferation; • positive regulation of apoptotic process; • regulation of cell motility; • negative regulation of apoptotic process; • cellular response to epidermal growth factor stimulus; • positive regulation of tyrosine phosphorylation of STAT protein; • positive regulation of protein kinase B signaling; • positive regulation of receptor signaling pathway via JAK-STAT; • synapse assembly; • negative regulation of signal transduction; • cell differentiation;
	Sources:Amigo / QuickGO
Orthologau
	2066
	n/a
	ENSG00000178568
	n/a
	Q15303
	n/a
	NM_001042599; NM_005235
	n/a
	NP_001036064; NP_005226
	n/a
	Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn ERBB4 yw ERBB4 a elwir hefyd yn Receptor tyrosine-protein kinase erbB-4 ac Erb-b2 receptor tyrosine kinase 4 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 2, band 2q34.^[2]

Cyfystyron[golygu | golygu cod]

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn ERBB4.

HER4
ALS19
p180erbB4

Llyfryddiaeth[golygu | golygu cod]

"Association between ErbB4 single nucleotide polymorphisms and susceptibility to schizophrenia: A meta-analysis of case-control studies. ". Medicine (Baltimore). 2017. PMID 28225484.
"ERBB4 Expression in Ovarian Serous Carcinoma Resistant to Platinum-Based Therapy. ". Cancer Control. 2017. PMID 28178720.
"ERBB4 gene polymorphisms and the risk of prostate cancer in a sample of Iranian Population. ". Cell Mol Biol (Noisy-le-grand). 2016. PMID 27609473.
"ErbB Receptor Tyrosine Kinase: A Molecular Switch Between Cardiac and Neuroectoderm Specification in Human Pluripotent Stem Cells. ". Stem Cells. 2016. PMID 27324647.
"Analysis of regulatory mechanism after ErbB4 gene mutation based on local modeling methodology.". Genet Mol Res. 2016. PMID 27323039.

Cyfeiriadau[golygu | golygu cod]

[1] "Human PubMed Reference:".

[2] ERBB4 - Cronfa NCBI

[1]

[2]