ERBB3

ERBB3
Strwythurau
PDB	Human UniProt search: PDBe RCSB
Rhestr o ddynodwyr PDB
	1M6B, 2L9U, 3KEX, 3LMG, 3P11, 4LEO, 4OTW, 4P59, 4RIW, 4RIX, 4RIY, 5CUS
Dynodwyr
Cyfenwau	ERBB3, ErbB-3, HER3, LCCS2, MDA-BF-1, c-erbB-3, c-erbB3, erbB3-S, p180-ErbB3, p45-sErbB3, p85-sErbB3, erb-b2 receptor tyrosine kinase 3, FERLK, VSCN1
Dynodwyr allanol	OMIM: 190151 HomoloGene: 20457 GeneCards: ERBB3
Patrwm RNA pattern
	Rhagor o gyfeiriadau
Ontoleg y genyn
Gweithrediad moleciwlaidd	• transferase activity; • nucleotide binding; • protein kinase activity; • protein tyrosine kinase activator activity; • growth factor binding; • protein homodimerization activity; • kinase activity; • GO:0001948, GO:0016582 protein binding; • identical protein binding; • protein heterodimerization activity; • ATP binding; • transmembrane signaling receptor activity; • neuregulin binding; • phosphatidylinositol-4,5-bisphosphate 3-kinase activity; • protein tyrosine kinase activity; • ubiquitin protein ligase binding; • receptor tyrosine kinase; • neuregulin receptor activity; • transmembrane receptor protein tyrosine kinase activity;
Cydrannau o'r gell	• integral component of membrane; • lateral plasma membrane; • bilen; • Cellbilen; • integral component of plasma membrane; • extracellular region; • basolateral plasma membrane; • apical plasma membrane; • intracellular anatomical structure; • receptor complex; • extracellular space; • cytoplasm; • basal plasma membrane;
Prosesau biolegol	• neuron apoptotic process; • negative regulation of cell adhesion; • phosphorylation; • endocardial cushion development; • positive regulation of protein tyrosine kinase activity; • wound healing; • MAPK cascade; • positive regulation of calcineurin-NFAT signaling cascade; • heart development; • protein phosphorylation; • negative regulation of secretion; • regulation of cell population proliferation; • extrinsic apoptotic signaling pathway in absence of ligand; • phosphatidylinositol 3-kinase signaling; • positive regulation of phosphatidylinositol 3-kinase signaling; • negative regulation of signal transduction; • GO:0072468 signal transduction; • cranial nerve development; • GO:1904089 negative regulation of neuron apoptotic process; • Schwann cell differentiation; • phosphatidylinositol phosphate biosynthetic process; • regulation of cell motility; • peripheral nervous system development; • transmembrane receptor protein tyrosine kinase signaling pathway; • ERBB2 signaling pathway; • peptidyl-tyrosine phosphorylation; • positive regulation of cardiac muscle tissue development; • GO:1901313 positive regulation of gene expression; • positive regulation of protein kinase B signaling; • cell differentiation; • negative regulation of apoptotic process; • positive regulation of ERK1 and ERK2 cascade; • nervous system development; • positive regulation of cell population proliferation;
	Sources:Amigo / QuickGO
Orthologau
	2065
	n/a
	ENSG00000065361
	n/a
	P21860
	n/a
	NM_001982; NM_001005915
	n/a
	NP_001005915; NP_001973
	n/a
	Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn ERBB3 yw ERBB3 a elwir hefyd yn Erb-b2 receptor tyrosine kinase 3 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 12, band 12q13.2.^[2]

Cyfystyron[golygu | golygu cod]

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn ERBB3.

HER3
LCCS2
ErbB-3
c-erbB3
erbB3-S
MDA-BF-1
c-erbB-3
p180-ErbB3
p45-sErbB3
p85-sErbB3

Llyfryddiaeth[golygu | golygu cod]

"Engineered Multivalency Enhances Affibody-Based HER3 Inhibition and Downregulation in Cancer Cells. ". Mol Pharm. 2017. PMID 28248115.
"Prognostic impact of HER3 based on protein and mRNA expression in high-grade serous ovarian carcinoma. ". Virchows Arch. 2017. PMID 27913862.
"HER3 Expression Is a Marker of Tumor Progression in Premalignant Lesions of the Gastroesophageal Junction. ". PLoS One. 2016. PMID 27559738.
"Integrated and Functional Genomics Analysis Validates the Relevance of the Nuclear Variant ErbB380kDa in Prostate Cancer Progression. ". PLoS One. 2016. PMID 27191720.
"HER3 expression is correlated to distally located and low-grade colon cancer.". Acta Oncol. 2016. PMID 26863446.

Cyfeiriadau[golygu | golygu cod]

[1] "Human PubMed Reference:".

[2] ERBB3 - Cronfa NCBI

[1]

[2]