ERAP1

ERAP1
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 2YD0, 3MDJ, 3QNF, 3RJO
Dynodwyr
Cyfenwau	ERAP1, A-LAP, ALAP, APPILS, ARTS-1, ARTS1, ERAAP, ERAAP1, PILS-AP, PILSAP, endoplasmic reticulum aminopeptidase 1
Dynodwyr allanol	OMIM: 606832 HomoloGene: 140581 GeneCards: ERAP1
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • interleukin-6 receptor binding • peptide binding • zinc ion binding • metal ion binding • interleukin-1, type II receptor binding • GO:0070122 peptidase activity • GO:0001948, GO:0016582 protein binding • aminopeptidase activity • metalloexopeptidase activity • hydrolase activity • metallopeptidase activity • endopeptidase activity • metalloaminopeptidase activity Cydrannau o'r gell • cytoplasm • integral component of membrane • cytosol • endoplasmic reticulum membrane • bilen • extracellular region • Reticwlwm endoplasmig • extracellular exosome • extracellular space • endoplasmic reticulum lumen • Cellbilen Prosesau biolegol • regulation of innate immune response • adaptive immune response • response to bacterium • immune system process • antigen processing and presentation of peptide antigen via MHC class I • proteolysis • positive regulation of angiogenesis • membrane protein ectodomain proteolysis • angiogenesis • fat cell differentiation • peptide catabolic process • antigen processing and presentation of endogenous peptide antigen via MHC class I • regulation of blood pressure • GO:0072468 signal transduction • cell-cell signaling Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	51752	n/a
Ensembl	ENSG00000164307	n/a
UniProt	Q9NZ08	n/a
RefSeq (mRNA)	NM_001040458 NM_001198541 NM_016442 NM_001349244	n/a
RefSeq (protein)	NP_001035548 NP_001185470 NP_057526 NP_001336173	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn ERAP1 yw ERAP1 a elwir hefyd yn Endoplasmic reticulum aminopeptidase 1 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 5, band 5q15.

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn ERAP1.

• ALAP
• A-LAP
• ARTS1
• ERAAP
• APPILS
• ARTS-1
• ERAAP1
• PILSAP
• PILS-AP

Llyfryddiaeth

• "Associations between ERAP1 polymorphisms and susceptibility to ankylosing spondylitis: a meta-analysis. ". Clin Rheumatol. 2016. PMID 27108589.
• "ERAP1 reduces accumulation of aberrant and disulfide-linked forms of HLA-B27 on the cell surface. ". Mol Immunol. 2016. PMID 27107845.
• "Critical Role of Interdomain Interactions in the Conformational Change and Catalytic Mechanism of Endoplasmic Reticulum Aminopeptidase 1. ". Biochemistry. 2017. PMID 28218509.
• "Single Nucleotide Polymorphisms of the ERAP1 Gene and Risk of NSCLC: A Comparison of Genetically Distant Populations, Chinese and Caucasian. ". Arch Immunol Ther Exp (Warsz). 2016. PMID 28083613.
• "Association between single nucleotide polymorphisms in prospective genes and susceptibility to ankylosing spondylitis and inflammatory bowel disease in a single centre in Turkey.". Turk J Gastroenterol. 2016. PMID 27458846.