EPS15

EPS15
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 1C07, 1EH2, 1F8H, 1FF1, 2IV9, 2JXC, 4RH5, 4RH9, 4RHG, 4S0G, 5JP2
Dynodwyr
Cyfenwau	EPS15, AF-1P, AF1P, MLLT5, epidermal growth factor receptor pathway substrate 15
Dynodwyr allanol	OMIM: 600051 HomoloGene: 128359 GeneCards: EPS15
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • calcium ion binding • SH3 domain binding • metal ion binding • polyubiquitin modification-dependent protein binding • GO:0001948, GO:0016582 protein binding • cadherin binding • identical protein binding • cargo receptor activity Cydrannau o'r gell • endosome • clathrin coat of coated pit • early endosome membrane • bilen • intracellular membrane-bounded organelle • Cellbilen • aggresome • ciliary membrane • clathrin-coated pit • AP-2 adaptor complex • clathrin-coated vesicle • basal plasma membrane • apical plasma membrane • early endosome • cytoplasm • cytosol • synapse • postsynapse • glutamatergic synapse Prosesau biolegol • negative regulation of epidermal growth factor receptor signaling pathway • endocytosis • epidermal growth factor receptor signaling pathway • vesicle organization • Golgi to endosome transport • clathrin coat assembly • protein transport • viral entry into host cell • receptor-mediated endocytosis of virus by host cell • cell population proliferation • positive regulation of receptor recycling • regulation of cell population proliferation • endocytic recycling • membrane organization • GO:0022415 viral process • GO:0015915 transport • postsynaptic neurotransmitter receptor internalization Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	2060	n/a
Ensembl	ENSG00000085832	n/a
UniProt	P42566	n/a
RefSeq (mRNA)	NM_001159969 NM_001981	n/a
RefSeq (protein)	NP_001153441 NP_001972	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn EPS15 yw EPS15 a elwir hefyd yn Epidermal growth factor receptor pathway substrate 15 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 1, band 1p32.3.

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn EPS15.

• AF1P
• AF-1P
• MLLT5

Llyfryddiaeth

• "Over-expression of EPS15 is a favorable prognostic factor in breast cancer. ". Mol Biosyst. 2015. PMID 26289382.
• "UIM domain-dependent recruitment of the endocytic adaptor protein Eps15 to ubiquitin-enriched endosomes. ". BMC Cell Biol. 2014. PMID 25260758.
• "Molecular characterization of identical, novel MLL-EPS15 translocation and individual genomic copy number alterations in monozygotic infant twins with acute lymphoblastic leukemia. ". Haematologica. 2012. PMID 22581003.
• "Role of receptor-mediated endocytosis in the formation of vaccinia virus extracellular enveloped particles. ". J Virol. 2005. PMID 15767409.
• "A ubiquitin-interacting motif (UIM) is essential for Eps15 and Eps15R ubiquitination.". J Biol Chem. 2002. PMID 12072436.